Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
The E.Coli derived recombinant mosaic protein contains the gp46 immunodominant regions, 162-214 amino acids and 242-257 amino acids, Mw on SDA-PAGE is 39kDa.
HTLV-1 gp46 was purified by proprietary chromatographic technique.
HTLV-1 gp46 protein is >95% pure as determined by 10% SDS-PAGE (coomassie staining) and RP-HPLC.
10mM NaPO4 pH 6.0, 0.1% SDS, 1mM DTT, 1mM EDTA.
HTLV-1 gp46 although stable at 4°C for 1 week, should be stored below -18°C.
Please prevent freeze thaw cycles.
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