prospec

CDCA8 Human

  • Name
  • Description
  • Pricings
  • Quantity
  • CDCA8 Human
  • Cell Division Cycle Associated 8 Human Recombinant
  • Shipped with Ice Packs

Catalogue number

PRO-222

Synonyms

Cell division cycle associated 8, BOR, hDasraB, FLJ12042, MESRGP, Pluripotent embryonic stem cell-related gene 3 protein, PESCRG3, BOREALIN.

Introduction

CDCA8 is a component of the chromosomal passenger complex (CPC). The CPC complex has crucial functions at the centromere in ensuring accurate chromosome placement and isolation and is obligatory for chromatin-induced microtubule stabilization and spindle assembly. In the complex, CDCA8 protein is needed to direct the CPC to centromeric DNA. Removal of CDCA8 delays mitotic progression and causes kinetochore-spindle to mis-attach.

Description

CDCA8 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 283 amino acids (19-280a.a.) and having a molecular mass of 31.6kDa.
The CDCA8 is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered colorless solution.

Formulation

The CDCA8 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 50% glycerol, 1mM DTT, 1mM EDTA and 0.2M NaCl.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. 
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by SDS-PAGE.

Amino acid sequence

MGSSHHHHHH SSGLVPRGSH MRKLASFLKD FDREVEIRIK QIESDRQNLL KEVDNLYNIE ILRLPKALRE MNWLDYFALG GNKQALEEAA TADLDITEIN KLTAEAIQTP LKSAKTRKVI QVDEMIVEEE EEEENERKNL QTARVKRCPP SKKRTQSIQG KGKGKRSSRA NTVTPAVGRL
EVSMVKPTPG LTPRFDSRVF KTPGLRTPAA GERIYNISGN GSPLADSKEI FLTVPVGGGE SLRLLASDLQ RHSIAQLDPE ALGNIKKLSN RLAQICSSIR THK

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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