Ubiquinol-Cytochrome C Reductase

Ubiquinol-Cytochrome C Reductase

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About Ubiquinol-Cytochrome C Reductase:

Ubiquinol-Cytochrome C Reductase, also known as UQCRC and sometimes called Complex III is the usual third element in the Electron Transport Chain, which plays a significant role in the biochemical production of (oxidative phosphorylation) ATP. This element is a multiple subunit transmembrane protein that is encoded by mitochondrial as well as nuclear genomes. This protein can be found in all eukaryotes, the internal membranes of almost all eubacteria, and the mitochondria of all animals.

UQCRC Structure
The number of subunits found in this element is small, like three polypeptides likened to the other key proton-pumping sub elements. In higher animals, this number can increase up to eleven subunits.
Three subunits have prosthetic assemblies, which are the Cytochrome b subunit with binary b-type hemes, Cytochrome c subunit with a single c-type heme, and Rieske iron-sulfur protein subunit that has two iron, and two sulfur (2Fe.2S).
The Complex III is located in the center of the respiratory chain tolerant electrons from the Complexes I, II, flavoproteins that transfer electrons and other flavoproteins through Ubiquinol.

Ubiquinol-Cytochrome C Reductase Interaction
There are 98 protein-protein interactions in UQCRC, 90 of which are co-complex interactions. Mapk3, QCR1, CAC1A, STOM, CACNA1A, and HLA-B have all been found to i9netact with UQCRC.

UQCRC Function
The Ubiquinol – Cytochrome C Reductase plays a major role as an energy transducing and energy transference enzyme found in the inner mitochondrial membrane of oxygen-using eukaryotic cells; this protein takes part in cell respiration.
The protein coded by this gene is located in the mitochondrion, where it is part of the UQCRC. It is also part of the mitochondrial respiratory chain. The core protein UQCRC is needed for the collection and stabilization of the complex.