TRIM21 Human

TRIM21 Human

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  • Description
  • Cat#
  • Pricings
  • Quantity
  • TRIM21 Human

  • Tripartite Motif Containing 21 (RO52) Human Recombinant
  • PRO-328
  • Shipped with Ice Packs

Catalogue number



52 kDa Ro protein, Sjoegren syndrome type A antigen, SS-A, Ro(SS-A), 52 kDa ribonucleoprotein autoantigen Ro/SS-A, Tripartite motif-containing protein 21, RING finger protein 81, TRIM21, RNF81, RO52, SSA1, SSA, RO-52.


TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The 52 kDa Ro protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. Ro/SSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Ribonucleoprotein particle is composed of a single polypeptide and one of four small RNA molecules. The RoSSA is present in all mammalian cells studied but has no known function. At least 2 isoforms are present in nucleated and red blood cells, and tissue specific differences in Ro/SSA proteins were identified.


TRIM21 Human Recombinant produced in SF9 is a polypeptide chain having a calculated  molecular mass of 52 kDa.
TRIM21 is expressed with a -6x His tag at N-terminus and purified by proprietary chromatographic techniques.


Sf9 insect cells.

Physical Appearance

Sterile Filtered clear solution.


TRIM21 solution is supplied in 20mM HEPES pH-7.5, 0.01mM EDTA and 0.02% SDS.


Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. 
Avoid multiple freeze-thaw cycles.


Greater than 95% as determined by SDS-PAGE.


1. Title:graft-versus-host disease Recovery of B-cell homeostasis.
Publication:doi:10.1182/blood-2010-10-307819 Prepublished online November 19, 2010;2011 117: 2275-2283.
Link:TRIM21 prospec publication

Safety Data Sheet


Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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