About TGFBI / Transforming Growth Factor Beta Induced:
TGFBI is a gene that produces proteins that influence cell proliferation and migration. The protein is released from cells and becomes part of the extracellular matrix, which can influence bone development. Crucially, corruption in this gene can cause congenital conditions such as corneal dystrophy.
TGFBI stands for “Transforming growth factor, beta-induced”, which is a protein found in humans. Proteins are large biomolecules and macromolecules that form long chains of amino acids. These carry out essential functions in the body relating to metabolism and DNA replication. These proteins are encoded in the TGBFI gene.
The TGFBI gene encodes proteins that bind to certain types of collagen and is thought to influence the extracellular matrix. This matric modulates cell adhesion and plays an important role in cell-collagen interactions. This process could be influential to the formation of bone in the fetus.
Transforming Growth Factor Beta Induced structure
The TGFBI gene is a cytokine protein important for cell signalling; the gene is part of the transforming growth factor superfamily along with some mammalian isoforms. White blood cell lineages predominantly produce them. The gene proteins and isoforms combine to regulate cell functions, cell proliferation, and cell migration.
This gene not only influences bone formation in the fetus, but corruptions of it can cause corneal dystrophies. These are hereditary conditions that produce volumes of substance in the translucent part of the eye - this leads to glare, blurred, or cloudy vision. It can also lead to blindness.