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Tumor Necrosis Factor

  • Name
  • Description
  • Pricings
  • Quantity
  • TNFRSF10A Human
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  • TRAIL Receptor-1 Human Recombinant
  • Shipped with Ice Packs
  • APRIL Human
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  • APRIL Human Recombinant
  • Shipped with Ice Packs
  • APRIL Mouse
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  • APRIL Mouse Recombinant
  • Shipped at Room temp.
  • LTBR Human
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  • Lymphotoxin Beta Receptor Human Recombinant
  • Shipped with Ice Packs
  • TACI Human, Sf9
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  • Tumor Necrosis Factor Receptor 13B Human Recombinant, Sf9
  • Shipped with Ice Packs
  • TACI Human
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  • Tumor Necrosis Factor Receptor 13B Human Recombinant
  • Shipped at Room temp.
  • TACI Human, His
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  • Tumor Necrosis Factor Receptor 13B Human Recombinant, His Tag
  • Shipped with Ice Packs
  • TNF a Canine
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  • Tumor Necrosis Factor-Alpha Canine Recombinant
  • Shipped at Room temp.
  • TNF a Human, HEK
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  • Tumor Necrosis Factor-alpha Human Recombinant, HEK
  • Shipped at Room temp.
  • TNF a Human, His
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  • Tumor Necrosis Factor-Alpha Human Recombinant, His Tag
  • Shipped at Room temp.
  • TNF a Human, Sf9
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  • Tumor Necrosis Factor-alpha Human Recombinant, Sf9
  • Shipped with Ice Packs
  • TNF a Mouse
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  • Tumor Necrosis Factor-Alpha Mouse Recombinant
  • Shipped at Room temp.
  • TNF a Mutant Human
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  • Tumor Necrosis Factor-Alpha Mutant Human Recombinant
  • Shipped at Room temp.
  • TNF a Rabbit
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  • Tumor Necrosis Factor-Alpha Rabbit Recombinant
  • Shipped at Room temp.
  • TNF a Rat
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  • Tumor Necrosis Factor-Alpha Rat Recombinant
  • Shipped at Room temp.
  • TNF a Rat, His
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  • Tumor Necrosis Factor-alpha Rat Recombinant, His Tag
  • Shipped with Ice Packs
  • TNF a Rhesus Macaque
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  • Tumor Necrosis Factor-Alpha Rhesus Macaque Recombinant
  • Shipped at Room temp.
  • TNF alpha human
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  • Tumor Necrosis Factor-Alpha Human Recombinant
  • Shipped at Room temp.
  • TNF b Human
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  • Tumor Necrosis Factor-Beta Human Recombinant
  • Shipped at Room temp.
  • TNF b Human, His
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  • Tumor Necrosis Factor-Beta Human Recombinant, His Tag
  • Shipped with Ice Packs
  • TNF B Human, Sf9
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  • Tumor Necrosis Factor-beta Human Recombinant, Sf9
  • Shipped with Ice Packs
  • TNFA Mouse, Sf9
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  • Tumor Necrosis Factor-alpha Mouse Recombinant, Sf9
  • Shipped with Ice Packs
  • TNFAIP8 Human
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  • Tumor Necrosis Factor, Alpha-Induced Protein 8 Human Recombinant
  • Shipped with Ice Packs
  • TNFR (22-211) Human
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  • Tumor Necrosis Factor Receptor (22-211 a.a.) Human Recombinant
  • Shipped with Ice Packs
  • TNFR Human
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  • Tumor Necrosis Factor Receptor Human Recombinant
  • Shipped at Room temp.
  • TNFR Human, His
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  • Tumor Necrosis Factor Receptor Type Human Recombinant, His Tag
  • Shipped with Ice Packs
  • TNFR Human, Sf9
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  • Tumor Necrosis Factor Receptor, sf9 Human Recombinant
  • Shipped with Ice Packs
  • TNFR Mouse
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  • Tumor Necrosis Factor Receptor Mouse Recombinant
  • Shipped at Room temp.
  • TNFR2 Human
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  • Tumor Necrosis Factor Receptor Type 2 Human Recombinant
  • Shipped at Room temp.
  • TNFR2 Human Fc
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  • Tumor Necrosis Factor Receptor 2 Fusion Protein Human Recombinant
  • Shipped at Room temp.
  • TNFR2 Human, His
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  • Tumor Necrosis Factor Receptor Type 2 Human Recombinant, His Tag
  • Shipped with Ice Packs
  • TNFR2 Human, Sf9
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  • Tumor Necrosis Factor Receptor Type 2 Human Recombinant, Sf9
  • Shipped with Ice Packs
  • TNFR2 Mouse
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  • Tumor Necrosis Factor Receptor Type 2 Mouse Recombinant
  • Shipped at Room temp.
  • TNFRSF10A Human Fc
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  • TRAIL Receptor-1 Human Recombinant Fc
  • Shipped at Room temp.
  • TNFRSF10B Human
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  • TNF Ligand Receptor Superfamily Member 10B Human Recombinant
  • Shipped at Room temp.
  • TNFRSF10C Human
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  • TRAIL Receptor-3 Human Recombinant
  • Shipped with Ice Packs
  • TNFRSF10D Human
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  • TRAIL Receptor-4 Human Recombinant
  • Shipped with Ice Packs
  • TNFRSF12A Human
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  • TNF Ligand Receptor Superfamily Member 12A Human Recombinant
  • Shipped at Room temp.
  • TNFRSF12A Human, sf9
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  • TNF Ligand Receptor Superfamily Member 12A Human Recombinant, Sf9
  • Shipped with Ice Packs
  • TNFRSF14 Human
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  • HVEM-Fc Human Recombinant
  • Shipped at Room temp.
  • TNFRSF14 Human, His
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  • HVEM Human Recombinant, His Tag
  • Shipped with Ice Packs
  • TNFRSF14 Human, Sf9
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  • HVEM-Fc Human Recombinant , Sf9
  • Shipped with Ice Packs
  • TNFRSF17 Human
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  • B-Cell Maturation Antigen Human Recombinant
  • Shipped at Room temp.
  • TNFRSF17 Human, His
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  • B-Cell Maturation Antigen Human Recombinant, His Tag
  • Shipped with Ice Packs
  • TNFRSF21 Human
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  • TNF Ligand Receptor Superfamily Member 21 Human Recombinant
  • Shipped with Ice Packs
  • TNFRSF25 Human
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  • TNF Ligand Receptor Superfamily Member 25 Recombinant Human
  • Shipped with Ice Packs
  • TNFRSF4 Human
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  • TNF Receptor Superfamily Member 4 Human Recombinant
  • Shipped with Ice Packs
  • TNFRSF6B Human
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  • Tumor Necrosis Factor Receptor Superfamily, Member 6b Human Recombinant
  • Shipped with Ice Packs
  • TNFRSF8 Human
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  • CD30 Ligand Receptor Human Recombinant
  • Shipped with Ice Packs
  • TNFRSF8 igG-His Human
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  • CD30 Ligand Receptor, IgG-His Tag Human Recombinant
  • Shipped with Ice Packs
  • TNFSF12 Human
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  • TNF Ligand Superfamily Member 12 Human Recombinant
  • Shipped at Room temp.
  • TNFSF14 Mouse
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  • LIGHT Mouse Recombinant
  • Shipped at Room temp.
  • TNFSF7 Human
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  • CD70 Human Recombinant
  • Shipped with Ice Packs
  • TNFSF7 Human, sf9
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  • CD70, sf9 Human Recombinant
  • Shipped with Ice Packs
  • TNFSF8 Human
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  • CD30 Ligand Human Recombinant
  • Shipped with Ice Packs
  • TNFSF8 Human, Sf9
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  • CD30 Ligand Human Recombinant, Sf9
  • Shipped with Ice Packs
  • TRAIL Human
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  • TRAIL / APO2 Ligand Human Recombinant
  • Shipped at Room temp.
  • TRAIL Human (114-281 a.a.)
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  • TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant
  • Shipped with Ice Packs
  • TRAIL Human (114-281 a.a.), Active
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  • TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant, Active
  • Shipped with Ice Packs
  • TRAIL Mouse
    More Info
  • TNF-Related Apoptosis Inducing Ligand/Apo2L Mouse Recombinant
  • Shipped at Room temp.

About Tumor Necrosis Factor:


Tumor necrosis factor alpha is a protein that’s part of the cytokine family. Cytokines are a rather diverse category of proteins that are essential when it comes to cell signalling. This particular cytokine - TNF Alpha - is one of the cell signalling proteins that form the acute phase reaction.

Mechanism/Interactions
TNF Alpha is primarily created by the activation of macrophages. These are a grouping of white blood cells that serve to ingest anything that doesn’t contain typical health body cell proteins. However, TNF Alpha can also be produced by multiple other cell types in the body. This includes mast cells, neurons, CD4+ lymphocytes, NK cells, eosinophils, and even neutrophils. This protein has also been discovered to interact with TNFR1, or tumour necrosis factor receptor 1. In doing so, it can bind this receptor with TNFR2. TNFR1 is most commonly abundant in the majority of tissue cells in the body. TNF can activate this receptor in both its membrane-bound and soluble forms. On the other hand, TNFR2 is commonly present in the immune system, and will only be activated by the membrane-bound form or TNF. These two receptors work together to send signals throughout cells.

Function
The main function of TNF Alpha is to regulate the immune cells. It has the ability to induce a fever, speed up cell death, create inflammation, and so much more. TNF is released in vast quantities when bacterial products such as lipopolysaccharide and interleukin-1 are present.
It works in many different ways with different parts of the body. More often than not, TNF will work alongside IL-1 and IL-6. It stimulates the acute phase response on the liver, which can lead to a growing amount of C-reactive protein in this organ. Furthermore, TNF functions to bring about insulin resistance, which prevents blood sugar levels from properly decreasing.
When concentration levels of TNF are increased, it leads to inflammation signs such as swelling, pain, and redness. Abnormally high levels of TNF have also been linked to a wasting syndrome that causes the body to drastically lose weight at an unhealthy rate. This is often common in cancer patients.
Therefore, many inflammatory diseases have been treated by using a TNF inhibitor. This prevents TNF Alpha from functioning properly, reducing the signs of inflammation.

Structure
TNF Alpha is largely arranged in stable homotrimers. It is a 233-amino acid long protein, of the type II transmembrane family. sTNF - which is the soluble homotrimeric cytokine - is released from TNF when it is in the membrane-bound form. When concentration reaches a nanomolar level or below, the soluble TNF begins to lose some of its bioactivity.
When secreted, the human form of TNF Alpha become triangular in its shape, almost resembling a pyramid. While in this form, TNF Alpha ways approximately 17-kD. The secreted form, along with the membrane-bound form, are both incredibly active on a biological scale. Both forms of TNF do have certain functions that are controversial with one another. However, they also have various biological activities that overlap and interlink with one another too.
This protein is mainly created and induced by cells in the epithelium right on barrier surfaces.