Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.
Human Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 660 kDa (330 kDa per subunit).
Human thyroid glands.
Sterile Filtered Off-White lyophilized (freeze-dried) powder.
Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.
Use phosphate buffer, pH>7.0 containing 0.15M NaCl is recommended.
Greater than 98.0%.
Human Thyroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8°C.
Human Virus Test
Starting material tested and certified negative for HIV I & II antibodies, Hepatitis B surface antigen, Hepatitis C antibodies, Syphilis and HIV-1/HBV/HCV NAT.