Thyroglobulin Human

Thyroglobulin Human

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  • Thyroglobulin Human

  • Thyroglobulin Human
  • PRO-443
  • Shipped at Room temp.

Catalogue number



Thyroglobulin, TGN, AITD3, TG.


Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.
Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.


Human Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 660 kDa (330 kDa per subunit).


Human thyroid glands.

Physical Appearance

Sterile Filtered Off-White lyophilized (freeze-dried) powder.


Lyophilized from 0.02M NH4HCO3. May contain traces of buffer salts.


Use phosphate buffer, pH>7.0 containing 0.15M NaCl is recommended.


Greater than 98.0%.


Human Thyroglobulin although stable at room temperature for 3 weeks, should be stored between 2-8°C.

Human Virus Test

Starting material tested and certified negative for HIV I & II antibodies, Hepatitis B surface antigen, Hepatitis C antibodies, Syphilis and HIV-1/HBV/HCV NAT.

Safety Data Sheet


Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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