Thymosins are a group of peptides that were originally isolated from the thymus gland. They are a small peptide with a molecular weight 1000-15000Da. The most prominent Thymosins can be found in a range of mammalian tissues.
Thymosin Mechanism & Function
The Thymosins have been categorized as biological response modifiers because they regulate cell migration, immune responses, and angiogenesis. There is a lot of key evidence to suggest that Thymosins are a key regulator of tissue regeneration and it also has a large role to play in skeletal regeneration. Thymosin is secreted from platelets and also encourages the formation of crosslinks with fibrin, which aids clot formation.
Thymosin is an acidic protein that doesn’t contain any lipid, nucleotides or carbohydrate. It has been used in adult mice to reduce scar formation and prevent mycote death, with incredibly promising results that can be expanded on in future trials.
Thymosin is currently being used for clinical applications, using a thymosin fraction with similar chemical and biological properties that has been prepared from human thymus glands. A prime example of this is its effectiveness in treating patients with ST elevation myocardial infarction. However, it only produces results when used in conjunction with other methods of treatment.
It also has potential applications in diseases caused by failures of development and maintenance of acceptable levels of immunological competence. These diseases include but are not limited to, primary immunodeficiencies, autoimmune diseases and malignancies. Preliminary clinical studies suggest that further exploration of the potential clinical benefits of Thymosin is needed as the initial results are very promising.