|Thrombopoietin is a glycoprotein hormone produced mainly by the liver and the kidney which regulates the production of platelets by the bone marrow. TPO stimulates the production as well as differentiation of megakaryocytes, the bone marrow cells which fragment into large numbers of platelets.
Thrombopoietin Human Recombinant produced in CHO cells has a molecular weight range of 80-90kDa due to glycosylation.
The TPO is purified by proprietary chromatographic techniques.
Chinese Hamster Ovary Cells.
TPO protein solution contains phosphate buffered saline (pH7.4) and 2% albumin.
Thrombopoietin although stable at room temperature for 1 week, should be stored between 2-8°C.
Greater than 98% as determined by SDS-PAGE.
The ED50 as determined by the dose-dependent stimulation of MO7e cells corresponding to a specific activity of 3x105 units/mg.