About STIP1 / Stress-Induced-Phosphoprotein 1:
Phosphoprotein stress-inducible protein (STIP11) is a less well-characterized member of the STING family that was recently discovered. Phosphoprotein is not induced by general cellular stresses, but it responds to specific conditions such as oxidative DNA damage, and DNA replication blockade.
Stress-induced-phosphoprotein (STIP1) is a protein that takes part in the activation of the mammalian digestive system. It is involved in signaling and its effectiveness has been found to be dependent on the cellular composition of the gut.
The existence of STIP11 is vital to our ability to digest and absorb food and survive.
Some studies have indicated that phosphoprotein STIP1 interacts with cAMP receptor protein/cAMP response element-binding protein (CREB) signaling pathway in mammalian cells. It may be involved in protection against oxidative DNA damages. In addition, some studies have suggested that this protein may also play a role in the sensitization of cells to chemotherapeutic agents.
Stress-Induced-Phosphoprotein 1 Expression
This protein has been found in the different tissues and organs of the body, such as skeletal muscle and kidneys. Furthermore, phosphoprotein STIP1 is also reported to be expressed on cells of various cancers including primary tumors of the breast, lung, pancreas, ovary, and colon tumor as well as those in triple-negative breast cancer (TNBC). The level of phosphoprotein STIP1 is also elevated in metastatic leiomyosarcoma cells.