About SSR / Signal Sequence Receptor:
SSR is a signal sequence receptor protein that belongs to the serine/threonine kinases signal transduction pathway. It can be found in the cytosol of the eukaryotic cell, stabilized by a signal peptide that serves as an import signal for protein translocation into wall-less organelles.
SSR Protein Structure
Within cells, the SSR structure has a small cytoplasmic N Terminal signal sequence followed by four homologous domains (D1–D4), with each domain consisting of two-stranded antiparallel beta-sheets surrounded by eight alpha-helices. The C Terminal portion contains a short helical hairpin and five leucines residues; which are involved in dimerization of the SSR protein.
Signal Sequence Receptor Interactions
There are some signal sequence receptor partner proteins, such as signal sequence binding protein 1(SSBP1), signal peptide peptidase (SPP), signal peptide factor 2 (SPF2) and signal recognition particle (SRP). The signal sequence receptor holds a central part in regulating intracellular transport and targeting signals. SSR signal sequence receptor protein-binding proteins can regulate signal blockade and signal recognition.
Signal sequence receptor is one of the key elements in the signal transduction pathway. Signal sequence receptor plays a role in targeting the signal peptide to certain organelles. To recognize and distinguish between intracellular transport signals, signal receptors are needed since intracellular transport sequencer (IDS) or signal peptide transporter (SPT) can't recognize all types of intracellular transport signals
Signal Sequence Receptor Cellular Location
The cytosol of the eukaryotic cell, stabilized by a signal peptide that serves as an import signal for protein translocation into wall-less organelles. signal sequence receptors are composed of a signal peptide, signal recognition particle (SRP), signal sequence binding protein 1(SSBP1) and signal sequence receptor.
In the signal pathway, signal receptors bind to substrates with specific intracellular transport signals and control the direction of divergent transport. Signal proteins have a transit peptide at their N terminus that directs them into organelles while targeting proteins typically lack a signal segment. Proteins destined for the nucleus are directed there through interaction with the nuclear localization signal (NLS) in many cases.