prospec
SHBG Protein

SHBG Protein

  • Name
  • Description
  • Cat#
  • Pricings
  • Quantity
  • SHBG Protein

  • Sex Hormone-Binding Globulin Human
  • PRO-2757
  • Shipped at Room temp.

Catalogue number

PRO-2757

Synonyms

Sex hormone-binding globulin, SHBG, Sex steroid-binding protein, SBP, Testis-specific androgen-binding protein, ABP, Testosterone-estradiol-binding globulin, TeBG, Testosterone-estrogen-binding globulin, SHBG.

Introduction

Sex-hormone-binding globulin (SHBG) is a beta-globulin which specifically binds steroid hormones; it is involved in the transport of sex steroids in plasma. The main site of SHBG synthesis is assumed to be the hepatocytes. The production of SHBG is regulated by androgen/estrogen balance, thyroid hormones, insulin and dietary factors, among others. The concentration of SHBG is a key factor regulating their distribution between protein-bound and free states. SHBG concentration determination is primarily significant in the evaluation of mild disorders of androgen metabolism and it allows detection of women with hirsutism who are likely to react to estrogen therapy. Testosterone/SHBG-ratios correlate well with both measured and calculated values for free testosterone thus aid to distinguish between subjects with excessive androgen activity and normal individuals. SHBG gene polymorphisms are linked with polycystic ovary syndrome and type 2 diabetes mellitus.

Description

SHBG is a protein of approximately 45kD.

Source

Human serum.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

The protein was lyophilized from 20mM NH4HC03 solution.
May contain traces of buffer salts.

Solubility

It is recommended to reconstitute the lyophilized SHBG in phosphate buffer, pH >7.0 containing 0.15M NaCl.

Stability

Lyophilized SHBG although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution SHBG should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Purity

>90% as visualized by SDS-Page.

Human Virus Test

FDA approved Plasma from each donor has been tested and found negative for antibodies to HIV-1 & 2, HCV, HBsAG, Parvovirus B19, HBc, HBV, HIV and Syphilis.

Safety Data Sheet

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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