About SPIN / Serine Peptidase Inhibitor:
Serine peptidase inhibitor, also known as SPIN, encoded by the SPINT2 gene, and also called Kunitz-type protease inhibitor 2, is an enzyme inhibitor.
SPIN is a transmembrane protein, meaning it spans the entirety of the cell membrane, acting as gateways to inhibit the movement of serine proteases. Serine proteases cleave peptide bonds in proteins. As such, SPIN may act as a tumor suppressor, preventing the passages of HGF activator which, in turn, prevents the formation of hepatocyte growth factor, which is secreted by mesenchymal cells and targets epithelial cells, endothelial cells, hemopoietic progenitor cells, and T cells.
Serine Peptidase Inhibitor Mechanism
SPIN mechanisms have been observed in suppressing OSCC cell migration and invasion, where it was seen that it contains gelatinolytic bands sensitive to GM6001, suggesting the presence of pro-matrix metalloprotease (MMP)-2 and -9. There is also evidence that the primary target protease for HAI-2 in the epithelial cell is prostasin.
SPIN interacts with a range of other proteins, including AP5M1 AP-5 complex subunit mu-1 ), PRSS3 (Serine Protease 3), C19orf33 (Chromosome 19 Open Reading Frame 33), SLC26A3 (Solute Carrier Family 26 Member 3), EPCAM (Epithelial Cell Adhesion Molecule), MYO5B (Myosin VB), PRSS8 (Serine Protease 8), ST14 (ST14 Transmembrane Serine Protease Matriptase), and MST1 (Macrophage Stimulating 1) .
Serine Peptidase Inhibitor Structure
SPIN has a size of 252 amino acids and a molecular mass of 28228 Da.