About SRGN / Serglycin:
Serglycin is a protein found in humans that is encoded by the SRNG gene, and is also known as SRNG for short. It is also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein.
The primary function of this gene is to encode the protein known as a hematopoietic cell granule proteoglycan. These glycosylated proteins are contained in hematopoietic cells, stem cells that give rise to other blood cells through hematopoiesis. Their purpose in these cells may be to neutralize hydrolytic enzymes.
The specifics of the exact molecular mechanism of serglycin are unclear at the current time of writing. It is known that serglycin secretory mechanisms show that it is secreted in monocytes or macrophages, myeloma cells, and human endothelial cells and that it is stored in secretory granules and secreted after cells activation in neutrophils and mast cells.
Serglycin interacts with different compounds depending on which cells they were in. In mast cells, they interact with carboxypeptidase, chymase, histamine, and trypaste. In neutrophils, they interact with elasatae. In cytotoxic T cells, they interact with granzyme B. In endothelial cells, they react with tissue-type plasminogen activators. Lastly, in macrophages, they interact with tumor necrosis factor-alpha.
Serglycin is currently the only known intracellular proteoglycan. It is located in chromosome 10q.22.1 in humans, and consists of 1.b kb of 5’-flanking DNA and three exons.