About RAET / Retinoic Acid Early Transcript:
Retinoic acid is an active form of vitamin A and plays a major role in the regulation of gene transcription. Retinoic acid early transcript (RAET) is necessary for retinoid-induced differentiation in some systems. RAET1E can bind to cellular receptors that are structurally related to members of the nuclear receptor family. This includes;
●Retinoid X receptors (RXRs)
●Constitutive androstane receptor (CAR)
●Peroxisome proliferator-activated receptors γ/δ (PPARγ/δ).
The mechanism of Retinoic Acid Early Transcript is unknown, but it may be a molecular response to ultraviolet light. There are two hypotheses for the trigger: (a) The body's natural defense system responds to damage. It does this by producing Retinoic Acid Early Transcript as part of repair processes that take place long after the injury or infection has healed, or (b) Retinoic Acid Early Transcript is a protective response to the initial injury.
It has been suggested that Retinoic Acid Early Transcript prevents cells from mutating and thus helps to prevent cancerous growths or tumours. However, the gene encoding for RETINOIC ACID EARLY TRANSCRIPT also encodes other proteins in the cell, so it is unclear how this gene operates to prevent cancer.
Retinoic Acid Early Transcript Structure
Retinoic Acid is a molecule that consists of three atoms: two carbon, one hydrogen, and four oxygen. The structure is related to vitamin A through its common side chain, which has an alcohol functionality attached at either end. What differentiates retinoids from other molecules in this family is their functional groups on the other end of the side chain.
Retinoic Acid is capable of interacting with other drugs. This interaction can be increased or decreased by the specific drug, its dose, frequency, and patient age, and disease severity. For example, it may interact with corticosteroids to cause hypercalcemia.
One important thing to note about Retinoid Acids is that it interacts with estrogen and progesterone. This interaction can cause an increase or decrease in the levels of these hormones, depending on which hormone was taken at a higher dose.