prospec

Protein Kinases

  • Name
  • Description
  • Pricings
  • Quantity
  • ACKA E.Coli
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  • Acetate Kinase E.Coli Recombinant
  • Shipped with Ice Packs
  • AKAP7 Human
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  • A Kinase Anchor Protein 7 Human Recombinant
  • Shipped with Ice Packs
  • BLK Human
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  • B lymphoid tyrosine kinase Human Recombinant
  • Shipped with Ice Packs
  • BRAF Human
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  • B-Raf Proto-Oncogene Human Recombinant
  • Shipped with Ice Packs
  • CKB Human
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  • Creatine Kinase Brain Human Recombinant
  • Shipped with Ice Packs
  • CKS2 Human
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  • CDC28 Protein Kinase 2 Human Recombinant
  • Shipped with Ice Packs
  • CMPK1 Human
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  • Cytidine Monophosphate Kinase 1 Human Recombinant
  • Shipped with Ice Packs
  • COAA E.Coli
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  • Pantothenate Kinase E.Coli Recombinant
  • Shipped with Ice Packs
  • CSK Human
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  • C-Src Tyrosine Kinase Human Recombinant
  • Shipped with Ice Packs
  • DCK Human
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  • Deoxycytidine Kinase Human Recombinant
  • Shipped with Ice Packs
  • DTYMK Human
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  • Deoxythymidylate Kinase Human Recombinant
  • Shipped with Ice Packs
  • DYRK1A Human
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  • Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated 1A Human Recombinant
  • Shipped with Ice Packs
  • ETNK2 Human
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  • EthanolamineKinase 2 Human Recombinant
  • Shipped with Ice Packs
  • Flavokinase Human
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  • Riboflavin Kinase Human Recombinant
  • Shipped with Ice Packs
  • GALK1 Human
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  • Galactokinase 1 Human Recombinant
  • Shipped with Ice Packs
  • GLK E.coli
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  • Glucokinase E.coli Recombinant
  • Shipped with Ice Packs
  • GlpK E. coli
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  • Glycerol kinase E. Coli Recombinant
  • Shipped with Ice Packs
  • HYKK Human
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  • Hydroxylysine Kinase Human Recombinant
  • Shipped with Ice Packs
  • IDNK E.Coli
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  • Thermosensitive Gluconokinase E.Coli Recombinant
  • Shipped with Ice Packs
  • ILK1 Human
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  • Integrin Linked Kinase Human Recombinant
  • Shipped with Ice Packs
  • IP6K2 Human
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  • Inositol Hexakisphosphate Kinase 2 Human Recombinant
  • Shipped with Ice Packs
  • ITPK1 Human
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  • Inositol-Tetrakisphosphate 1-Kinase Human Recombinant
  • Shipped with Ice Packs
  • JAK2 Human
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  • Janus Kinase 2 Human Recombinant
  • Shipped with Ice Packs
  • Ketohexokinase Human
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  • Ketohexokinase Human Recombinant
  • Shipped with Ice Packs
  • KIT Human
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  • KIT Proto-Oncogene Receptor Tyrosine Human Recombinant
  • Shipped with Ice Packs
  • MAPK13 Human
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  • Mitogen-Activated Protein Kinase 13 Human Recombinant
  • Shipped with Ice Packs
  • MAPKAPK3 Human
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  • Mitogen-Activated Protein Kinase-Activated Protein Kinase 3 Human Recombinant
  • Shipped with Ice Packs
  • MEK1 Human
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  • Mitogen Activated Kinase Kinase 1 Human Recombinant
  • Shipped with Ice Packs
  • MERTK Mouse
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  • MER Proto-Oncogene Tyrosine Kinase Mouse Recombinant
  • Shipped with Ice Packs
  • MOB1B Human
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  • MOB Kinase Activator 1B Human Recombinant
  • Shipped with Ice Packs
  • MOB3B Human
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  • MOB Kinase Activator 3B Human Recombinant
  • Shipped with Ice Packs
  • MVK Human
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  • Mevalonate Kinase Human Recombinant
  • Shipped with Ice Packs
  • NAGK Human
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  • N-Acetylglucosamine Kinase Human Recombinant
  • Shipped with Ice Packs
  • NDK E.Coli
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  • Nucleoside Diphosphate Kinase E.Coli Recombinant
  • Shipped with Ice Packs
  • NEK7 Human
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  • NIMA-related kinase 7 Human Recombinant
  • Shipped with Ice Packs
  • NME2 Rat
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  • Non-Metastatic Cells 2 Rat Recombinant
  • Shipped with Ice Packs
  • NNMT Mouse
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  • Nicotinamide N-Methyltransferase Mouse Recombinant
  • Shipped with Ice Packs
  • p38a/SAPK2 Human
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  • p38a/SAPK2 Human Recombinant
  • Shipped with Ice Packs
  • PAK4 Human
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  • p21 Activated Kinase 4 Human Recombinant
  • Shipped with Ice Packs
  • PBK Human
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  • PDZ Binding Kinase Human Recombinant
  • Shipped with Ice Packs
  • PCK1 Human
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  • Phosphoenolpyruvate Carboxykinase 1 Human Recombinant
  • Shipped with Ice Packs
  • PDK1 Human
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  • Pyruvate Dehydrogenase Kinase Isozyme 1 Human Recombinant
  • Shipped with Ice Packs
  • PDXK Human
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  • Pyridoxal Kinase Human Recombinant
  • Shipped with Ice Packs
  • PFKM Human
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  • Phosphofructokinase, Muscle Human Recombinant
  • Shipped with Ice Packs
  • PGK1 Human
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  • Phosphoglycerate Kinase 1 Human Recombinant
  • Shipped with Ice Packs
  • PGK1 Mouse
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  • Phosphoglycerate Kinase 1 Mouse Recombinant
  • Shipped with Ice Packs
  • PGK2 Human
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  • Phosphoglycerate Kinase 2 Human Recombinant
  • Shipped with Ice Packs
  • PICK1 Human
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  • Protein Interacting With PRKCA 1 Human Recombinant
  • Shipped with Ice Packs
  • PINK1 Human
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  • PTEN Induced Putative Kinase 1 Human Recombinant
  • Shipped with Ice Packs
  • PIP4K2B Human
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  • Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, Beta Human Recombinant
  • Shipped with Ice Packs
  • PKIB Human
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  • Protein Kinase Inhibitor Beta Human Recombinant
  • Shipped with Ice Packs
  • PKLR Human
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  • Pyruvate Kinase, Liver and RBC Human Recombinant
  • Shipped with Ice Packs
  • PKM2 Human
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  • Tumor Type M2 Pyruvate Kinase Human Recombinant
  • Shipped with Ice Packs
  • PKM2 Mouse
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  • Tumour Type M2 Pyruvate Kinase Mouse Recombinant
  • Shipped with Ice Packs
  • PMVK Human
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  • Phosphomevalonate Kinase Human Recombinant
  • Shipped with Ice Packs
  • PRKAA1 Human
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  • Protein Kinase, AMP-Activated, Alpha 1 Human Recombinant
  • Shipped with Ice Packs
  • PRKAB1 Human
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  • Protein Kinase, AMP-Activated, Beta 1 non-Catalytic Subunit Human Recombinant
  • Shipped with Ice Packs
  • PRKAB2 Human
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  • Protein Kinase, AMP-Activated, Beta 2 non-Catalytic Subunit Human Recombinant
  • Shipped with Ice Packs
  • PRKACB Human
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  • Protein Kinase CAMP-Dependent Catalytic Beta Human Recombinant
  • Shipped with Ice Packs
  • PRKAG1 Human
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  • Protein Kinase, AMP-Activated, Gamma 1 Human Recombinant
  • Shipped with Ice Packs
  • PRKAR2A Human
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  • Protein Kinase CAMP-Dependent Regulatory Type II Alpha Human Recombinant
  • Shipped with Ice Packs
  • PRKRA Human
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  • Protein Kinase IFN Double Stranded RNA Activator Human Recombinant
  • Shipped with Ice Packs
  • pykF E.Coli
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  • Pyruvate Kinase I E.Coli Recombinant
  • Shipped with Ice Packs
  • RBKS Human
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  • Ribokinase Human Recombinant
  • Shipped with Ice Packs
  • SGK1 Human
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  • Serum/Glucocorticoid Regulated Kinase 1 Human Recombinant
  • Shipped with Ice Packs
  • SKP1 Alpha Human
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  • S-phase Kinase-Associated Protein 1 Isoform A Human Recombinant
  • Shipped with Ice Packs
  • Staphylokinase
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  • Staphylokinase Recombinant
  • Shipped at Room temp.
  • STAT1 Human
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  • Signal Transducer and Activator of Transcription 1 Human Recombinant
  • Shipped with Ice Packs
  • STAT3 Human
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  • Signal Transducer and Activator of Transcription 3 Human Recombinant
  • Shipped with Ice Packs
  • Streptokinase
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  • Streptokinase Recombinant
  • Shipped at Room temp.
  • SYK Human
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  • Spleen Tyrosine Kinase Human Recombinant
  • Shipped with Ice Packs
  • TK1 Human
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  • Thymidine Kinase 1 Human Recombinant
  • Shipped with Ice Packs
  • TK2 Human
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  • Thymidine Kinase 2 Human Recombinant
  • Shipped with Ice Packs
  • TPK1 Human
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  • Thiamin Pyrophosphokinase 1 Human Recombinant
  • Shipped with Ice Packs
  • TPMT Human
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  • Thiopurine S-methyltransferase Human Recombinant
  • Shipped with Ice Packs
  • TRIB3 Human
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  • Tribbles Pseudokinase 3 Human Recombinant
  • Shipped with Ice Packs
  • TSSK2 Human
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  • Testis Specific Serine Kinase 2 Human Recombinant
  • Shipped with Ice Packs
  • TSSK6 Human
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  • Testis Specific Serine Kinase 6 Human Recombinant
  • Shipped with Ice Packs
  • UCK1 Human
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  • Uridine-Cytidine Kinase 1 Human Recombinant
  • Shipped with Ice Packs
  • UCK2 Human
    More Info
  • Uridine-Cytidine Kinase 2 Human Recombinant
  • Shipped with Ice Packs

About Protein kinases:

Protein kinases are a group of kinase enzymes found within the human body. The list of roughly 500 protein kinase genes make up about 2% of human genes. The enzymes alter other proteins through a process known as phosphorylation, which is where phosphate groups are added to them.

Protein Kinase Structure
Protein kinases are enzymes located in the cytoplasm that phosphorylates proteins. The chief enzymes consist of PKA, PKG, PKC, and tyrosyl protein kinases. The eukaryotic protein kinases belong to a wide and varied family of proteins that boast a shared conserved catalytic core. The N-terinal of the catalytic domain contains glycine residues close to the lysine amino aid, having an influence on ATP binding Meanwhile, the central region of the catalyic domain has a conserved aspartic acid.
Phosphorylation of the proteins is very quick due to the rapid dephosphorylate of previously phosphorylated cells, resulting in the termination of the intracellular signal. By regulating the biological activity of proteins, the protein kinases induce a change from inactivity to activity within the target cells.
Examples of human proteins including the protein kinase domain include but are not limited to; AAK1, AATK, ARAF, AURKA, AXL, BLK, BMPR1A, BMPR1B, BMX, CAMK4, CDK1, CDK10, CHUK, CIT, DYRK1A, DYRK1B, EGFR, FER, FES, GAK, HUNK, IT, KSR1, KSR2, LCK, LIMK1, LIMK2, MAP2K5, MYLK4, NRK, OXRS1, PLK1, PLK2, POMK, RET, ROCK1, ROCk2, SIK1, SIK2, LK, TEC, TEK, ULK1, ULK2, WEE1, and ZAP70.

Protein Kinase Function and Mechanisms
As the largest enzyme superfamily related to cell signal transduction, protein kinases are therapeutic targets for various diseases. Protein kinases can, through phosphorylation, alter protein functions in several ways. It may increase or decrease the protein’s activity, stabilize it, or even lead to its destruction.
The enzymes can also localize the protein while regulating the enzyme too. Because it is a reversible covalent modifications, prosphorylation is seen to be regulatory. Allosteric control, for example, responds to signals outside of the cell. The phosphorylation is more frequent in eukaryotic cells than prokaryotic cells due to their wider response rate.
Pathways affected by protein kinases include metabolism, cell signalling, protein regulation, cellular transport, secretory processes. Protein kinases will influence both activity and reactivity, as well as binding mechanisms in relation to other molecules.

Protein Kinase Interactions
Roughly 30% of all human proteins can be changed by the protein kinase activities, affecting signal transduction and other cellular pathways. The majority act on both serine and theonine while others interact with tyrosine. Dual-specificity kinases act on all three.Kinases are turned on or off by phosphorylation, having huge impact on the target cell.
The serine and theonine protein kinases phosphorylate the OH group and may be regulated by various events such as DNA damage, as well as chemical signals such as cAMP/cGMP, diacylglycerol, and Ca2+/calmodulin.
Another significant group of protein kinases is the mitogen-activated protein (MAP) kinases. protein phosphatases can limit the activity on the MAP kinases while the activation of transmembrane receptors via natural ligands or crosslinking agents send signals that include oxidant stress.