About ETS2 / Protein C-ETS:
Protein C-ETS2 is a protein in humans that is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.
The ETS2 gene encodes a transcription factor that regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in the regulation of telomerase. A pseudogene of this gene is located on the X chromosome.
ETS2 is implicated in:
●glucocorticoid receptor binding
●positive regulation of transcription from RNA polymerase II promoter
●positive regulation of transcription, DNA-dependent
●RNA polymerase II regulatory region sequence-specific DNA binding
●sequence-specific DNA binding transcription factor activity
●skeletal system development
ETS2 has been shown to interact with the following:
●C-jun, a protein encoded by the JUN gene
●Cyclin-dependent kinase 10, an enzyme in humans encoded by the CDK10 gene
●ERG (ETS-related gene), an oncogene that is a member of the ETS (erythroblast transformation-specific) family of transcription factors
●Myb, genes that are a part of a large gene family of transcription factors found in both animals and plants
●ZMYND11 (Zinc finger MYND domain-containing protein 11), a protein in humans encoded by the ZMYND11 gene
Protein C-ETS Functions
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
Its molecular functions include DNA binding, sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, and glucocorticoid receptor binding.