prospec

Phosphatase

  • Name
  • Description
  • Pricings
  • Quantity
  • ACP1 Human
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  • Acid Phosphatase-1 Human Recombinant
  • Shipped with Ice Packs
  • ACP2 Human
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  • Acid Phosphatase-2 Human Recombinant
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  • ACP5 Human
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  • Acid Phosphatase-5 Human Recombinant
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  • ACP5 Human, His
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  • Acid Phosphatase-5 Human Recombinant, His Tag
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  • ACP6 Human
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  • Acid Phosphatase-6 Human Recombinant
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  • ACPP Human
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  • Acid Phosphatase Prostate Human Recombinant
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  • ACPP Human, Sf9
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  • Acid Phosphatase Prostate, Human Recombinant, sf9
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  • ACYP1 Human
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  • Acylphosphatase 1 Human Recombinant
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  • Alkaline Phosphatase Bovine
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  • Alkaline Phosphatase Bovine Intestinal
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  • ALPL Mouse
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  • Alkaline Phosphatase Liver/Bone/Kidney Mouse Recombinant
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  • CTDSP1 Human
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  • CTD Small Phosphatase 1 Human Recombinant
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  • CTDSPL Human
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  • CTD Small Phosphatase-Like Human Recombinant
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  • DCTPP1 Human
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  • dCTP Pyrophosphatase 1 Human Recombinant
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  • DUSP10 Human
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  • Dual Specificity Phosphatase 10 Human Recombinant
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  • DUSP13 Human
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  • Dual Specificity Phosphatase 13 Human Recombinant
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  • DUSP18 Human
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  • Dual Specificity Phosphatase 18 Human Recombinant
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  • DUSP18 Human, Active
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  • Dual Specificity Phosphatase 18 Human Recombinant, Active
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  • DUSP19 Human
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  • Dual Specificity Phosphatase 19 Human Recombinant
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  • DUSP21 Human
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  • Dual Specificity Phosphatase 21 Human Recombinant
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  • DUSP22 Human
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  • Dual Specificity Phosphatase 22 Human Recombinant
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  • DUSP23 Human
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  • Dual Specificity Phosphatase 23 Human Recombinant
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  • DUSP23 Human, Active
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  • Dual Specificity Phosphatase 23 Human Recombinant, Active
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  • DUSP26 Human
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  • Dual Specificity Phosphatase 26 Human Recombinant
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  • DUSP3 Human
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  • Dual Specificity Phosphatase 3 Human Recombinant
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  • DUSP6 Human
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  • Dual Specificity Phosphatase 6 Human Recombinant
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  • DUT Human
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  • Deoxyuridine Triphosphatase Human Recombinant
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  • DUT Pyrococcus Fruriosus
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  • Thermostable dUTPase Pyrococcus Fruriosus Recombinant
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  • ENOPH1 Human
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  • Enolase-Phosphatase-1 Human Recombinant
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  • ENPP1 Human
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  • Ectonucleotide Pyrophosphatase Human Recombinant
  • Shipped at Room temp.
  • FBP1 Human
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  • Fructose-1,6-Bisphosphatase 1 Human Recombinant
  • Shipped with Ice Packs
  • FBP2 Human
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  • Fructose-1,6-Bisphosphatase 2 Human Recombinant
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  • IMPA1 Human
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  • Inositol Monophosphatase 1 Human Recombinant
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  • IMPA2 Human
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  • Inositol Monophosphatase 2 Human Recombinant
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  • ITPA Human
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  • Inosine Triphosphatase Human Recombinant
  • Shipped with Ice Packs
  • LHPP Human
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  • Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase Human Recombinant
  • Shipped with Ice Packs
  • MDP1 Human
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  • Magnesium-Dependent Phosphatase 1 Human Recombinant
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  • NANP Human
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  • N-Acetylneuraminic Acid Phosphatase Human Recombinant
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  • PDXP Human
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  • Pyridoxal Phosphatase Human Recombinant
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  • PGP Human
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  • Phosphoglycolate Phosphatase Human Recombinant
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  • PGP Human, Active
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  • Phosphoglycolate Phosphatase Human Recombinant, Active
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  • PHOSPHO1 Human
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  • Phosphatase Orphan-1 Human Recombinant
  • Shipped at Room temp.
  • PHOSPHO2 Human
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  • Phosphatase Orphan-2 Human Recombinant
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  • PHPT1 Human
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  • Phosphohistidine Phosphatase 1 Human Recombinant
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  • PHPT1 Human, Active
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  • Phosphohistidine Phosphatase 1 Human Recombinant, Active
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  • PLAP Human
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  • Placental Alkaline Phosphatase Human Recombinant
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  • PPA E.Coli
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  • Inorganic Pyrophosphatase E.Coli Recombinant
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  • PPA1 Human
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  • Pyrophosphatase-1 Human Recombinant
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  • PPA2 Human
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  • Pyrophosphatase-2 Human Recombinant
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  • PPM1A Human
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  • Protein Phosphatase 1A Alpha Isoform Human Recombinant
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  • PPM1D Human
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  • Protein Phosphatase 1D Human Recombinant
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  • PPM1F Human
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  • Protein Phosphatase 1F Human Recombinant
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  • PPM1G Human
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  • Protein Phosphatase 1G Human Recombinant
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  • PPM1G Human, 546 a.a.
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  • Protein Phosphatase 1G 546 a.a. Human Recombinant
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  • PPP1CA Human
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  • Protein Phosphatase 1, Catalytic Subunit Alpha Human Recombinant
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  • PPP1CC Human
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  • Protein Phosphatase 1, Catalytic Subunit Gamma Human Recombinant
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  • PPP1CC Human, Active
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  • Protein Phosphatase 1, Catalytic Subunit Gamma Human Recombinant, Active
  • Shipped with Ice Packs
  • PPP1R14A Human
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  • Protein Phosphatase-1 Regulatory Subunit-14A Human Recombinant
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  • PPP1R1A Human
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  • Protein Phosphatase Inhibitor-1 Human Recombinant
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  • PPP1R2 Human
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  • Protein Phosphatase 1, Regulatory Subunit 2 Human Recombinant
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  • PPP1R8 Human
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  • Protein Phosphatase 1, Regulatory Subunit 8 Human Recombinant
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  • PPP2R1A Human
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  • Protein Phosphatase 2, Regulatory Subunit A Alpha Human Recombinant
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  • PPP3CA Human
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  • Protein Phosphatase 3, Catalytic subunit, Alpha Isozyme Human Recombinant
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  • PPP3R1 Human
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  • Protein Phosphatase 3, Regulatory subunit, Alpha Isozyme Recombinant Human
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  • PPP3R2 Human
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  • Protein Phosphatase 3 Regulatory subunit, Beta Isozyme Human Recombinant
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  • PPP4C Human
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  • Protein Phosphatase 4 Catalytic subunit Human Recombinant
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  • PSPH Human
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  • Phosphoserine Phosphatase Human Recombinant
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  • RNGTT Human
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  • RNA Guanylyltransferase And 5'-Phosphatase Human Recombinant
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  • SSU72 Human
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  • SSU72 RNA Polymerase II CTD Phosphatase Human Recombinant
  • Shipped with Ice Packs
  • THTPA Human
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  • Thiamine Triphosphatase Human Recombinant
  • Shipped with Ice Packs

About Phosphatase:

Phosphatases are enzymes that use water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol molecule with a free hydroxyl group. Phosphatase enzymes work by catalyzing the hydrolysis of their substrate, and as such they are considered a subcategory of hydrolases.
Like all hydrolases, phosphatase enzymes are an essential catalyst in many biological functions, including cellular signaling and regulation via phosphorylation by protein kinases as well as dephosphorylation. Because they play such a key role in the of cells regulation, phosphatases are extremely valuable in the field of medical and pharmaceutical research. Phosphatase enzymes are not to be confused with phosphorylase enzymes. These catalyze the transfer of phosphate groups from hydrogen phosphate to an acceptor.

Phosphatase Mechanism
Phosphatases work by removing phosphate groups from molecules. Kinases, on the other hand work by catalyzing the transfer of phosphate groups to molecules from ATP synthase. Together, kinases and phosphatases combine to facilitate a form of post-translational modification that forms a key component of the regulatory network in every cell.
Phosphatases can dephosphorylate sites on their substrates which appear different in surprisingly specific ways, which brings us to...

Phosphatase Interactions and Functions
Studies reveal that so called "docking interactions" play a significant role in the binding of substrates. What makes phosphatase fascinating is their ability to recognize and interacts with various motifs of different substrates which bind with low affinity to docking sites on the phosphatase not contained within the active site. While each individual docking interaction is weak, when many interactions occur simultaneously this has a cumulative effect on the specificity of bindings.
Unlike kinases, phosphatase enzymes can recognize and catalyze broad range of substrates and reactions. In humans, for instance, Ser/Thr kinases outnumber Ser/Thr phosphatases ten to one. It’s worth noting that our incomplete knowledge of the human phosphatome (the complete set of phosphatases expressed in an organism, a tissue or its constituent cells) may at least partially account for this disparity.
It’s also important to note that many phosphatases have yet to be discovered, with a substrate yet to be identified for many of those that we do know. Nonetheless, well-studied phosphatase/kinase pairings consistently demonstrate that phosphatases exhibit greater variety in form and function than their kinase counterparts.
Protein phosphatases have even been observed to catalyze the dephosphorylation of nonprotein substrates. What’s more, dual-specificity tyrosine phosphatases can dephosphorylate serine residues as well as tyrosine residues, but also serine residues. As such, one single phosphatase can actually exhibit the properties of multiple phosphatase families.

Phosphatase Structure
The Enzyme Commission recognizes 104 distinct enzyme families within the larger class of phosphatases- although all still catalyze the same hydrolysis reaction. They are classified by the specificity of the substrate and the sequence homology of their catalytic domains.
In-vitro experiments have demonstrated that not only do phosphatase enzymes appear to recognize a wide range of different substrates, one substrate can be recognized by a range of different phosphatases. In-vivo experimentation, on the other hand, has shown phosphatase enzymes to be markedly more specific.