About PEX / Peroxisomal Biogenesis Factor protein:
The Peroxisomal Biogenesis Factor protein, PEX, is encoded by the gene PEX. This protein is a member of the peroxisome biogenesis factor family of proteins. It plays a vital role in liver development and lipid metabolism. The human PEX gene contains three exons and two introns, spans about 4 kb, and localizes to chromosome 6p22-p21.1 (6q24).
The mechanisms by which PEX gene products take part in liver development and lipid metabolism are not precise.
Peroxisomal Biogenesis Factor Protein Structure
PEX proteins contain two domains, an amino-terminal peroxisomal targeting sequence (PTT) domain with about 275 residues long and a carboxy-terminal catalytic domain with a Rossman fold.
The function of this enzyme is to catalyse the formation of plasmalogens by adding a long-chain fatty acid. Octadecyl acetate (C18:0) in type I peroxisomes and C20:0 acetic acid is usually in type II peroxisomes.
Peroxisomal Biogenesis Factor Protein Interactions
PEX protein interacts with a set of proteins, including the peroxisomal membrane protein PMP22, PXMP-13, and CXXC-type zinc finger proteins. More research is needed to elucis the mechanism, structure, and function of PEX.
Importance of PEX
PEX protein plays a crucial role in lipid metabolism, and it implicates in several pathophysiological processes, including cancer, liver development, aging of the brain.
Peroxisomal Biogenesis Factor Protein Positioning
The PEX protein is in the peroxisome, a cellular organelle that plays several roles in lipid metabolism. You can find it an interactor of other proteins and transcription factors essential for liver development and lipid metabolism.