prospec

Peptidase

  • Name
  • Description
  • Pricings
  • Quantity
  • MME Human
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  • Membrane Metalloendopeptidase Human Recombinant
  • Shipped with Ice Packs
  • Aminopeptidase
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  • Aminopeptidase Aeromonas Recombinant
  • Shipped with Ice Packs
  • ASPRV1 Human
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  • Aspartic Peptidase, Retroviral-Like 1 Human Recombinant
  • Shipped with Ice Packs
  • Carboxypeptidase B Rat
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  • Carboxypeptidase-B Rat Recombinant
  • Shipped at Room temp.
  • CASP2 Human
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  • Caspase 2 Apoptosis-Related Cysteine Peptidase Human Recombinant
  • Shipped with Ice Packs
  • CASP3 Human
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  • Caspase 3 Apoptosis-Related Cysteine Peptidase Human Recombinant
  • Shipped with Ice Packs
  • CLPP Human
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  • ClpP Caseinolytic Peptidase Human Recombinant
  • Shipped with Ice Packs
  • CNDP1 Human
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  • CNDP Dipeptidase 1 Human Recombinant
  • Shipped with Ice Packs
  • CNDP1 Human, Active
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  • CNDP Dipeptidase 1 Human Recombinant, Active
  • Shipped with Ice Packs
  • CNDP1 Mouse
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  • CNDP Dipeptidase 1 Mouse Recombinant
  • Shipped with Ice Packs
  • CNDP2 Human
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  • CNDP Dipeptidase 2 Human Recombinant
  • Shipped with Ice Packs
  • CPA4 Human
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  • Carboxypeptidase A4 Human Recombinant
  • Shipped with Ice Packs
  • CPE Human
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  • Carboxypeptidase-E Human Recombinant
  • Shipped with Ice Packs
  • DESI1 Human
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  • Desumoylating Isopeptidase 1 Human Recombinant
  • Shipped with Ice Packs
  • DPP4 Human
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  • Dipeptidyl-Peptidase 4 Human Recombinant
  • Shipped with Ice Packs
  • DPP4 Protein
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  • Human Dipeptidyl Peptidase-IV
  • Shipped at Room temp.
  • GLU-C S.aureus
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  • Glutamyl endopeptidase Staphylococcal Recombinant
  • Shipped at Room temp.
  • IMMP2L Human
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  • IMP2 Inner Mitochondrial Membrane Peptidase-Like Human Recombinant
  • Shipped with Ice Packs
  • LAP3 Human
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  • Leucine Aminopeptidase 3 Human Recombinant
  • Shipped with Ice Packs
  • Lysostaphin
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  • Lysostaphin Recombinant
  • Shipped at Room temp.
  • MAP E.coli
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  • Methionine Aminopeptidase E.Coli Recombinant
  • Shipped with Ice Packs
  • METAP1 Human
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  • Methionyl Aminopeptidase 1 Human Recombinant
  • Shipped with Ice Packs
  • METAP1D Human
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  • Methionyl Aminopeptidase 1D Human Recombinant
  • Shipped with Ice Packs
  • NAPSA Human
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  • Napsin A Aspartic Peptidase Human Recombinant
  • Shipped with Ice Packs
  • OSGEP Human
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  • O-Sialoglycoprotein Endopeptidase Human Recombinant
  • Shipped with Ice Packs
  • PCOLCE Human
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  • Procollagen C-Endopeptidase Enhancer Human Recombinant
  • Shipped with Ice Packs
  • PCOLCE Human, Sf9
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  • Procollagen C-Endopeptidase Enhancer Human Recombinant, Sf9
  • Shipped with Ice Packs
  • PEPD Human
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  • Peptidase D Human Recombinant
  • Shipped with Ice Packs
  • PGPEP1 Human
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  • Pyroglutamyl-Peptidase I Human Recombinant
  • Shipped with Ice Packs
  • PI16 Human
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  • Peptidase Inhibitor 16 Human Recombinant
  • Shipped at Room temp.
  • PREP Human
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  • Prolyl Endopeptidase Human Recombinant
  • Shipped with Ice Packs
  • SENP8 Human
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  • Sentrin Specific Peptidase Family Member 8 Human Recombinant
  • Shipped with Ice Packs
  • SERPINE2 Mouse
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  • Plasminogen Activator Inhibitor-2 Mouse Recombinant
  • Shipped with Ice Packs
  • SPINK1 Human
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  • Serine Peptidase Inhibitor Kazal Type 1 Human Recombinant
  • Shipped with Ice Packs
  • XPNPEP1 Human
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  • X-Prolyl Aminopeptidase-1 Human Recombinant
  • Shipped with Ice Packs

About Peptidase:

Peptidase is an umbrella term recommended by the International Union of Biochemistry and Molecular Biology and the Human Gene Nomenclature Committee. It is also commonly used in the MEROPS database. Peptidase is used to describe any enzyme that is capable of catalyzing the hydrolysis of a protein substrate and breaking it down into smaller polypeptides or amino acids. These proteins are also often referred to as protease or proteinase.
Peptidases are a key component of a number of common biological functions. The most obvious is in the digestion of eaten proteins. Without peptidase, the catalyzation might take years or even centuries. They also assist in the breakdown of old proteins (catabolism) as well as cell signaling. They occur in mammals, plants, bacteria and even viruses.

Peptidase Mechanism and Function
Peptidase breaks protein compounds down into amino acids by leaving the peptide bonds within proteins by hydrolysis. This means that water is used to break the bonds of protein structures.
This is achieved through one of the following two mechanisms depending on the specific kind of peptidase. Aspartic, glutamic and metallo peptidases, activate a water molecule. This in turn performs a nucleophilic (electron donating) attack on the peptide bond to hydrolyze it.
Serine, threonine and cysteine peptidases, form a nucleophilic residue which occurs as part of a catalytic triad. This residue performs the same nucleophilic attack albeit to different effect. The attack covalently bonds the peptidase to the substrate protein and the first half of the product is released. This covalent acyl-enzyme intermediate is subsequently hydrolyzed by activated water. This completes the catalysis by releasing the second half of the product and the free enzyme is regenerated.

Peptidase Interactions
Peptidases are classified based on their interactions and the nature of their catalysis. Each group of peptidases uses a different catalyst to facilitate one of the above mechanisms.
Some of these enzymes can be highly promiscuous, hydrolyzing a wide range of protein substrates. Others, however, can be very specific and cleave substrates in certain sequences to achieve precise events. The serine peptidase Thrombin, for example, requires this kind of specificity to facilitate blood clotting.
It’s worth noting that, as proteins, peptidases can also be cleaved by other peptidases, sometimes of the same variety.