- Name
- Description
- Cat#
- Pricings
- Quantity
Catalogue number
CYT-501
Synonyms
Glioma-derived growth factor, GDGF, Osteosarcoma-derived Growth Factor, ODGF, SIS, SSV, PDGF2, c-sis, FLJ12858, PDGF-BB, PDGF B-chain, Platelet-derived growth factor beta polypeptide.
Introduction
Description
Source
Physical Appearance
Formulation
Solubility
It is recommended to reconstitute the lyophilized Platelet-derived Growth Factor-BB in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability
Please prevent freeze-thaw cycles.
Purity
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Amino acid sequence
Biological Activity
The expected ED50 for this effect is 1.0-3.0 ng/ml.
References
1.Title:Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway.
Publication:Published online before print October 30, 2009, doi: 10.1182/blood-2009-06-223719 Blood January 7, 2010 vol. 115 no. 1 51-60 .
Link:PDGF BB prospec publication
2.Title: attenuates skeletal muscle dystrophy in mdx mice.
Publication:Published online before print March 16, 2009, doi: 10.1096/fj.09-129833 August 2009 The FASEB Journal vol. 23 no. 8 2539-2548.
Link:Platelet-Derived Growth Factor BB prospec publication
Safety Data Sheet
Usage
Background
Recombinant Human BB Platelet-Derived Growth Factor (PDGF-BB): Multifaceted Roles in
Development, Tissue Repair, and Disease Progression
Abstract:
Platelet-Derived Growth Factor BB (PDGF-BB), also known as ODGF, SIS, SSV, PDGF-BB, or PDGF B-chain, is a potent growth factor involved in numerous physiological and pathological processes.
This research paper aims to comprehensively explore the multifaceted roles of recombinant human PDGF-BB in development, tissue repair, and disease progression. Through an in-depth analysis of its molecular characteristics, signaling pathways, and diverse physiological functions, this paper provides insights into the significance of PDGF-BB as a
critical regulator in various biological contexts.
Introduction :
Platelet-Derived Growth Factor BB (PDGF-BB) is a growth factor that plays a pivotal role in diverse biological processes, including embryonic development, tissue repair, and disease progression. This section provides an introduction to PDGF-BB and its synonyms, such as ODGF, SIS, SSV, PDGF-BB, and PDGF B-chain, highlighting their relevance and significance in scientific literature.
Molecular Characteristics of PDGF-BB:
This section explores the molecular characteristics of PDGF-BB, including its primary amino acid sequence, protein structure, post-translational modifications, and binding partners. The importance of these factors in determining PDGF-BB's biological activity, receptor binding affinity, and downstream signaling pathways is discussed in detail.
Signaling Pathways Activated by PDGF-BB:
PDGF-BB engages specific signaling pathways upon binding to its receptors, leading to diverse cellular responses. This section focuses on the canonical PDGF receptor (PDGFR) signaling cascade, highlighting the activation of Ras/MAPK, PI3K/Akt, and PLCγ pathways. The downstream effectors and transcription factors involved in mediating PDGF-BB's cellular responses are also discussed.
Physiological Functions of PDGF-BB:
PDGF-BB plays crucial roles in various physiological processes, including embryonic development, angiogenesis, tissue repair, and homeostasis. This section examines PDGF-BB's contributions to cell proliferation, migration, differentiation, and survival, emphasizing its effects on specific cell types and tissues.
PDGF-BB in Disease Progression:
PDGF-BB is implicated in the progression of several diseases, including cancer, fibrosis, and vascular disorders. This section delves into PDGF-BB's involvement in tumor growth, angiogenesis, metastasis, tissue fibrosis, and vascular remodeling. The therapeutic implications and targeting of PDGF-BB in disease management are also discussed.
Clinical Applications and Future Perspectives:
Recombinant human PDGF-BB holds significant clinical potential for tissue repair, wound healing, and regenerative medicine. This section highlights the current applications of PDGF-BB in clinical settings, including bone and soft tissue repair, chronic wound management, and periodontal regeneration. Furthermore, it discusses ongoing research efforts and potential future directions in utilizing PDGF-BB for therapeutic purposes.
Conclusion :
Recombinant human PDGF-BB, also known as ODGF, SIS, SSV, PDGF-BB, or PDGF B-chain, plays multifaceted roles in development, tissue repair, and disease progression. Through its molecular characteristics, signaling pathways, and diverse physiological functions, PDGF-BB emerges as a critical regulator in various biological contexts.