About NPM / Nucleophosmin:
Nucleophosmin (NPM1), which you may see written as B23, No38, or Numatrin, is a protein present in the nuclei of proliferating cells that is abundant in the nuclei. NPM1 has been linked to ribosome biogenesis, mRNA processing, chromatin remodelling, and embryogenesis. While much is known about NPM1's role in metabolic pathways, it is more and more evident that NPM1 also plays an important role in genomic stability by participating in multiple DNA repair pathways and controlling apoptosis.
Nucleophosmin (NPM1) is a cellular protein that has been linked to a variety of processes such as mRNA transport, chromatin remodeling, apoptosis, and genome stability. NPM1 function is important for normal cellular functioning, as evidenced by the fact that NPM1 is frequently overexpressed, altered, rearranged, and sporadically eliminated in cancer. NPM1 may act as both a proto-oncogene and a tumor suppressor, indicating that it has a multifunctional role inside the cell. It would be useful to understand more about NPM1’s less well-known involvement in DNA repair pathways, as well as its role in the control of apoptosis and mutation in malignancies.
NPM1 is a member of the Nucleophosmin/nucleoplasmin (NPM) family of histone chaperones, which includes many main functional members (NPM1, NPM2, NPM3, and the invertebrate NPM-like) and is present in all Metazoans. While the operational characteristics of this family are well understood, little is known about the evolution of these genes and proteins.