EC 18.104.22.168, Matrix metalloproteinase-8, MMP-8, PMNL-CL, HNC, CLG1.
Full-length recombinant human neutrophil MMP-8, latent form.
Matrix metalloproteinase 8 (MMP-8), degrades interstitial collagens, acting preferentially on collagen type I.
Increased full-length MMP-8 protein was associated with infiltration into the skin of neutrophils, which are the major cell type that expresses MMP-8.
MMP-8 is synthesized and stored in specific granules in neutrophil leukocytes. MMP-8 activity is therefore regulated by factors such as surface-bound ligands (IgG or complement components) that release it through degranulation.Once released and activated through proteolytic or oxidative mechanisms, MMP-8 plays a major role in the connective tissue turnover that accompanies inflammatory processes.
The MMP-8 is purified by proprietary chromatographic techniques.
Avoid multiple freeze-thaw cycles.
One unit of collagenolytic activity is defined as the cleavage of 1µg of collagen per minute by the solution method.
Used as a standard for analyzing mammalian colagenase activity.