prospec

METRNL Human

  • Name
  • Description
  • Pricings
  • Quantity
  • METRNL Human
  • Meteorin-Like Protein Human Recombinant
  • Shipped at Room temp.

Catalogue number

PRO-2583

Synonyms

Meteorin-like protein, Subfatin, METRNL.

Introduction

METRNL or Meteorin-like protein is a hormone, released after physical activity (in skeletal muscle) or exposure to cold (in adipose tissue), that induces energy rate. METRNL stimulates energy rate correlate with white fat browning and raise glucose tolerance. The protein stimulates different types of immune cells to enter the fat tissue and start their prothermogenic actions.

Description

METRNL Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 46-311) containing 276 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 31.2kDa (calculated).

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized (freeze-dried) powder.

Formulation

METRNL filtered (0.4 µm) and lyophilized from 0.5mg/ml in 50mM acetate buffer, 5% trehalose (w/v) and 1mM DTT, pH 4.

Solubility

It is recommended to add 0.1M acetate buffer, pH 4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely.

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Purity

Greater than 95.0% as determined by SDS-PAGE.

Amino acid sequence

MKHHHHHHAS QYSSDRCSWK GSGLTHEAHR KEVEQVYLRC AAGAVEWMYP TGALIVNLRP NTFSPARHLT VCIRSFTDSS GANIYLEKTG ELRLLVPDGD GRPGRVQCFG LEQGGLFVEA TPQQDIGRRT TGFQYELVRR HRASDLHELS APCRPCSDTE VLLAVCTSDF AVRGSIQQVT HEPERQDSAI HLRVSRLYRQ KSRVFEPVPE GDGHWQGRVR TLLECGVRPG HGDFLFTGHM HFGEARLGCA PRFKDFQRMY RDAQERGLNP CEVGTD.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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