About Member RAS Oncogene Family:
Member RAS Oncogene Family consists of RAN, which is a Protein Coding gene. Diseases that are linked with this include the likes of Vici Syndrome and Teratocarcinoma. Among the related pathways include Transport of the SLBP Independent Mature mRNA and Metabolism. GTP binding is one of the Gene Ontology (GO) annotations that are linked to this gene.
Member RAS Oncogene Family Function
RAN is a GTP binding protein that is small in size and is part of the RAS superfamily that is deemed critical for translocating proteins and RNA through the complex of the nuclear pore. The RAN protein also plays a role in the progression of the cell cycle and in controlling DNA synthesis. For the RAN to be localized nuclearly, it needs there to be the existence of regulator of chromosome condensation 1, otherwise referred to as RCC1.
Member RAS Oncogene Family Mechanism
RAN regulates the organization and formation of the microtube network independently of the role that it has when it comes to the nucleus-cytosol macromolecule exchange. RAN may also play a chief role throughout mitosis in terms of signalling molecule regulating microtubule polymerization. A high concentration of RAN-GTP is generated by RCC1 around chromatin, which will mean the local nucleation of microtubules will be induced.