Mago-Nashi Homolog

Mago-Nashi Homolog

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About MAGOH / Mago-Nashi Homolog:

Mago nashi homolog is a protein that is encoded by the MAGOH gene when found in humans. Mutations in a mago nashi gene will result in offspring with defects in areas like germplasm assembly and germline development. It can be expressed in adult tissues and induced by serum simulation.

MAGOH Exon Junction Complex
The exon junction complex (EJC) is a structure with proteins and peripheral nuclear and cytoplasmic factors. They join during EJC assembly or during mRNA metabolism. The EJC is where the exon-exon junction is found in the mature mRNA for gene expression. It is also a main component for spliced mRNAs through all stages of their metabolism.

Mago-Nashi Homolog Splicing
About 20 nucleotides from the exon-exon junction, the RNA-binding protein Y14 prefers to bind with mRNAs that are produced during splicing. These have functions that are important in post-splicing events like nuclear export and nonsense-mediated decay of mRNA
MAGOH, a homolog of Drosophila mago nashi gene product found in humans, is a new part of this complex. It binds with Y14 and TAP, but not to any other components. It is found in Y14-containing mRNPs. It also binds to mRNAs produced during splicing upstream of exon-exon junctions. It’s binding to mRNA continues after export.

MAGOH Function
Two genes with MAGOH paralogs are shown in mammals. The expression of MAGOHB, but not MAGOH mRNA increases after LPS stimulation. Both of these proteins interact with EJC parts and incorporate into mRNA-bound EJCs. They also activate nonsense-mediated decay. The depletion of MAGOH and MAGOHB at the same time impair nonsense-mediated decay on human cells.