About ING / Inhibitor of Growth Family:
Inhibitor of growth protein 1, also known as ING1, is a protein that is encoded by the ING1 gene in humans. Diseases associated with ING1 include head and neck and squamous cell carcinoma and squamous cell carcinoma.
ING1 is characterized as a caretaker gene that controls the integrity of the genome. ING1 encodes a tumour suppressor protein that can induce cell growth arrest, and apoptosis (the death of cells that occurs as a normal and controlled part of growth and development). The encoded protein is a nuclear protein that physically interacts with TP53, the tumour suppressor protein. It is a component of the p53 signalling pathway. ING1 has also been described to interact with the Sin3/HDAC1/HDAC2/SAP30 complex through direct interactions with SAP30.
Reduced expression and rearrangement of ING1 have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have also been reported.
Inhibitor of Growth Family Location on Chromosome 13
ING1 is located near the following genes on Chromosome 13:
●CARKD Carbohydrate Kinase Domain-Containing Protein (Unknown Function)
●COL4A2: A2 Subunit of type IV collagen
●RAB20: Potential regulator of Connexin 43 trafficking.
●CARS2: Mitochondrial Cysteinyl-tRNA Synthetase 2
ING1 has been shown to interact with:
●CREB binding protein - A protein that in humans is encoded by the CREBBP gene.
●DMAP1 - DNA methyltransferase 1-associated protein 1.
●HDAC1 - Histone deacetylase 1.
●PCNA - Proliferating cell nuclear antigen, a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells.