About IMPAD1 / Inositol Monophosphatase Domain Containing 1:
Inositol monophosphatase 3, also known as inositol monophosphatase domain-containing protein 1 (IMPAD1), is an enzyme that is encoded by the IMPAD1 gene in humans. The gene is a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP).
IMPAD1 also functions as a mitochondrial electron transport inhibitor that prevents ROS production and also promotes the metastasis of lung cancer through the AMPK-Notch1-HEY1 pathway. Studies have identified IMPAD1 from the conditioned medium of highly-invasive CL1-5.
IMPAD1 may also play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.
Other aliases of IMPAD1 include BPNT2, GPAPP, IMP 3, IMP-3, IMPA3, inositol monophosphatase domain containing 1, IMPAD1, 3'(2'), and 5'-bisphosphate nucleotidase 2.
IMPAD1 Protein type
Cell development/differentiation; EC 18.104.22.168; EC 22.214.171.124; Membrane protein, integral; Phosphatase (non-protein)
Inositol Monophosphatase Domain Containing 1Cellular Components
Cytosol, Golgi apparatus, Golgi lumen, integral component of membrane, nuclear body, nucleus.
The main molecular functions of IMPAD1 include 3'(2'),5'-bisphosphate nucleotidase activity, inositol monophosphate 1-phosphatase activity, inositol monophosphate 3-phosphatase activity, inositol monophosphate 4-phosphatase activity, and metal ion binding.
Inositol Monophosphatase Domain Containing 1 Cellular Clinical significance
Mutations in the IMPAD1 gene are a cause of GRAPP-type chondrodysplasia with joint dislocations. A pseudogene of this gene is located on the long arm of chromosome 1.
Currently, there is no solved structure for IMPAD1.