IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kB pathways and stimulate the production of IFN-gamma. ). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.
IL-23 was lyophilized from a 0.1µm filtered solution (1.05mg/ml) containing 1xPBS.
It is recommended to reconstitute the lyophilized IL23 in sterile 1xPBS containing 0.1% endotoxin-free recombinant HSA.
Please prevent freeze-thaw cycles.
The activity, as determined by the dose dependent secretion of IL-17 in response to IL-23 using murine splenocytes, the ED50 is 1.9ng/ml.