prospec

HERV-K

  • Name
  • Description
  • Pricings
  • Quantity
  • HERV-K
  • Endogenous retrovirus K Envelope Human Recombinant
  • Shipped with Ice Packs

Catalogue number

HER-001

Introduction

HERVK is related with several tumors such as passenger virus, and anti-Retroviral therapy against amyotrophic lateral sclerosis/ALS has exhibited to decrease the symptoms of amyotrophic lateral sclerosis/ALS. High counts of viral sequences exist in the human genome but stay silent. Though, in pathological conditions, these viruses are produced. Human Endogenous Retrovirus-K, is produced in neurons of a subpopulation of patients with amyotrophic lateral sclerosis/ALS, a progressive neurodegenerative disease. The envelope protein of this HERV results in degeneration of neurons, and transgenic animals producing this protein advance an ALS-like syndrome triggered by nucleolar dysfunction in motor neurons. Reactivation of the HERVK is controlled by the transcription factor TDP-43. Therefore, therapeutic tactics against this virus alter the course of the disease.

Description

The E.Coli derived HERV-K recombinant truncated protein is fused to a Six histidine tag at C-terminus and has a MW of 51.5kDa (pI 9.06).

Source

Escherichia Coli.

Purity

Protein is >90% pure as determined by SDS PAGE.

Physical Appearance

Sterile Filtered clear solution.

Formulation

10mM Phosphate buffer pH 7.2.

Stability

HERV-K although stable at 4°C for 1 week, should be stored below -18°C.

Please prevent freeze thaw cycles.

Applications

Detection of Human Endogenious Retrovirus K in individuals is untested.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals.

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