prospec
HIV-2 gp160

HIV-2 gp160

  • Name
  • Description
  • Cat#
  • Pricings
  • Quantity
  • HIV-2 gp160

  • HIV-2 gp160 Recombinant
  • HIV-013
  • Shipped with Ice Packs

Catalogue number

HIV-013

Introduction

HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears and vaginal fluids. Immunodeficiency develops more slowly with HIV-2. HIV-2 is less infectious in the early stages of the virus than with HIV-1. The infectiousness of HIV-2 increases as the virus progresses. Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain, which is common to many viral and cellular fusion proteins and which seems to drive fusion.

HIV2 gp160 protein contains HIV2 Subtype A sequence, covering C4, V5, and C5 from HIV2 gp120 and extending to HIV2 gp36.

Description

HIV-2 gp160 produced in E. coli having a Mw of 41kDa.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

HIV-2 gp160 solution contains 0.025% NaN3, 25mM Tris-Base and 25mM K2CO3.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Protein is >95% pure as determined by 10% PAGE (coomassie staining).

Applications

Lateral flow immunoassay and ELISA test.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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