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HIV-1 p24 Paired

HIV-1 p24 Paired

  • Name
  • Description
  • Cat#
  • Pricings
  • Quantity
  • HIV-1 p24 Paired

  • Mouse Anti HIV-1 p24 Paired
  • ANT-772
  • Shipped with Ice Packs

Catalogue number

ANT-772

Introduction

Human immunodeficiency virus (HIV) is a retrovirus that can lead to a condition in which the immune system begins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the human immune system such as helper T cells (specifically CD4+ T cells), macrophage sand dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells; secondly, increased rates of apoptosis in infected cells; and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the Retroviridae family. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genome is converted to double-stranded DNA by a virally encoded reverse transcriptase that is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integrase so that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latent and the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells. The p24 protein is detected in patient blood as early as 2 weeks after HIV infection, further reducing the window period necessary to accurately detect the HIV status of the patient.

Type

Mouse Anti Human Monoclonal.

Description

HIV-1 p24 Paired antibodies coating and conjugating are used for lateral flow immunoassay and having a Mw of 24kDa.

Please note that when ordering for example: 100µg antibody we ship 50µg from each of the antibodies (100µg in total).

Purification Method

Purified by protein A affinity column.

Purity

Greater than 90%.

Physical Appearance

2 vials of sterile filtered clear colorless solution.

Formulation

*HIV-1 p24 coating antibody contains PBS, pH 7.4.

* HIV-1 p24 conjugating antibody contains PBS, pH 7.4.

Stability

HIV-1 p24 antibody although stable at 4°C for 1 week, should be stored below
-18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

Applications

Lateral flow immunoassay.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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