- Name
- Description
- Cat#
- Pricings
- Quantity
Catalogue number
HCV-273
Introduction
HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus belongs to the Flaviviridae family. HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes (1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6). Hepatitis C Virus 8th Generationis a mosaic fusion protein which contains multiple genecassettes including env – core - NS3 - NS4 – NS5 and covers genotype I, II and III.
Description
HCV 8th Generation produced in E. coli having a Mw of 80kDa.
Source
Escherichia Coli.
Physical Appearance
Sterile Filtered clear solution.
Formulation
HCV 8th solution contains 25mM K2CO3 and 50mM Tris-Base.
Stability
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Purity
Protein is >95% pure as determined by 12% PAGE (coomassie staining).
Applications
Lateral flow immunoassay and ELISA test.