About GABARAP / GABA(A) Receptor-Associated Protein:
Gamma-aminobutyric acid receptor-associated protein (GABA) A is a protein found in humans, vertebrates, and invertebrates. They are ligand-gates chloride channels involved in inhibitory neurotransmission. It is encoded by the GABARAP gene in the human genome.
GABARP was initially identified and its function was discovered and clarified back in 1957. An experienced team of Canadian researchers discovered that the compound responsible for the inhibitory activity in crayfish was, in fact, GABA. The first time this activity had ever been accounted for. This was subsequently confirmed by a number of other studies.
They play an important role in the human central nervous system. Research has shown that dysfunction of GABARAP in the localization of cell membranes, can be associated with a range of server psychiatric disorders that have a confirmed diagnosis.
GABARAP Function
The main function of GABARAP is an inhibitory neurotransmitter. It is found in the brain of humans as well as other vertebrates and invertebrates. By binding to the GABA receptors, it mediates neuronal inhibition in humans, vertebrates, and invertebrates.
Mutations of the gene that encodes GABARAP have been associated with seizure activity and epilepsy.
GABA(A) subunits go to assemble type A GABARP from the pentameric chloride channels.
GABA(A) Receptor-Associated Protein Interactions
There are a number of documented and confirmed GABARP interactions that exist. In tests and through computationally derived observations, GABARAP has been seen to interact with the following:
●Transferrin receptor protein 1 (TFRC)
●ULK1
●Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2)
Research is ongoing as to a number of other potential interactions.