prospec

FCMR Human

  • Name
  • Description
  • Pricings
  • Quantity
  • FCMR Human
  • Fc Fragment Of IgM Receptor Human Recombinant
  • Shipped at Room temp.

Catalogue number

PRO-2579

Synonyms

Fas apoptotic inhibitory molecule 3, IgM Fc fragment receptor, Regulator of Fas-induced apoptosis Toso, FAIM3, TOSO.

Introduction

Fas apoptotic inhibitory molecule 3 or FCMR takes part in processes occurring within the immune system. The FCMR is protecting cells from apoptosis that is induced by FADD, FAS and TNF alpha proteins, without over expressing inhibitors of apoptosis such as BCLXL or BCL2.  FCMR activates an inhibitory pathway that inhibits CASP8 activation, instead of blocking apoptotic signals downstream.

Description

FCMR Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 18-250) containing 243 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 27.2kDa (calculated).

Source

Escherichia Coli.

Physical Appearance

Filtered White lyophilized (freeze-dried) powder.

Formulation

FCMR filtered (0.4 µm) and lyophilized from 0.5mg/ml in 50mM acetate buffer, pH 4.

Solubility

It is recommended to add 0.1M acetate buffer, pH 4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. In higher concentrations the solubility of this antigen is limited.

Stability

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Purity

Greater than 95.0% as determined by SDS-PAGE.

Amino acid sequence

MKHHHHHHAS RILPEVKVEG ELGGSVTIKC PLPEMHVRIY LCREMAGSGT CGTVVSTTNF IKAEYKGRVT LKQYPRKNLF LVEVTQLTES DSGVYACGAG MNTDRGKTQK VTLNVHSEYE PSWEEQPMPE TPKWFHLPYL FQMPAYASSS KFVTRVTTPA QRGKVPPVHH SSPTTQITHR PRVSRASSVA GDKPRTFLPS TTASKISALE GLLKPQTPSY NHHTRLHRQR ALDYGSQSGR EGQ.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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