Exedin, or Exedin-4, is a peptide-1 receptor agonist protein. It is typically found and produced in the gut of a specific type of reptile found in desert surroundings. This peptide has commonly been used in many Diabetes Type 2 treatment discoveries as a way of facilitating glucose control. Unlike many other products in this area, it's one of the few that doesn't exhibit damaging side effects - such as excessive weight gain.
Extending-4 is a novel peptide with 39 amino acids making up its structure. It has a molecular weight of 4186.7 Dalton. When synthesised, it is used under the name Exenatide.
Exendin Mechanism & Function
Exedin is seen to bind with GLP-1R, which is a glucagon-like peptide-1 receptor in the human body. Studies have shown that it functions to help control glucose levels in the blood. It can stimulate the increase of insulin from the pancreas, lowering the rise in blood sugar after consuming food.
Unlike many Diabetes Type 2 treatments, exedin-4 allows insulin production to slow down once optimal glucose levels are reached in the blood. This prevents instances where too much insulin is produced, causing hypoglycemia (excessively low blood sugar). Exedin has also been linked to facilitating weight loss in Diabetes Type 2 patients.
Exedin-4 primarily interacts with receptors within the pancreas. From here, it enables the pancreas to increase insulin production and decrease glucagon release. Exedin also interacts with the digestive system to slow down gastric emptying and decrease the rate of glucose in the bloodstream following meals. It is also known to interact with the liver to reduce liver fat content.