About DCUN1D:
A Protein Coding gene, DCUN1D stands for Defective in Cullin Neddylation 1 Domain Containing 1. There are a number of different genes that are linked with DCUN1D. This includes the likes of Scrotum Squamous Cell Carcinoma and Squamous Cell Carcinoma. DCUN1D2 is a vital paralog of the DCUN1D gene.
The gene encoding Dcun1D2 is found on human chromosome 13. Chromosome 13 includes significant tumor suppressor genes, which includes BRCA2 and RB1. These are linked with breast cancer susceptibility and retinoblastoma, respectively.
DCUN1D Function
DCUN1D is part of an E3 ubiquitin ligase complex for neddylation. It promotes the neddylation of E3 cullin-RING ubiquitin ligase complexes cullin components.
DCUN1D Mechanism
It binds to cullin-RBX1 complexes within the cytoplasm, which promotes the nucleal translocation, which will enhance E2-NEDD8 (UBE2M-NEDD8) thioester recruitment to the complex and it will optimize the introduction of proteins within the complex so that NEDD8 can be transferred efficiently to the cullin substrates from the E2.
It is also part of the inhibitory effects of CAND1 on cullin-RING ligase E3 complex activity and assembly being released. It also acts as an oncogene, which facilitates carcinogenic progression and malignant transformation.