About CUEDC / CUE Domain Containing:
The CUE domain containing (CUEDC) protein acts on both the surface and underlying structures, and acts as a protein coding gene, entirely encoded by the CUEDC1 gene. This ensures that the protein molecule is not a monomer, and acts on a molecular level only binding ubiquitin, and often acts in a chain.
CUE Domain Containing Interactions
The CUEDC acts as a binder, and has its own domain. Within this domain, it binds in terms of both mono and polyubiquitin, and there are even some proteins that are ubiquitinylated in these binding terms alone, being entirely dependent on CUEDC itself. CUEDC acts on two proteins in the IL-1 signal transduction pathway, as well as human Tollip proteins, and in TAB2.
Research into the CUE Domain Containing, or CUEDC protein initially described a relation between the yeast Cue1 protein and human Tollip proteins. The region between the two is 40 amino acids long, and is found in a variety of proteins with differing functions. This includes the endoplasmic reticulum, in which the CUEDC protein helps to regulate misfolded proteins.
CUE Domain Containing Structure
Made up of a three-helix bundle model, and in terms of its structure, is related to the UBA domain, which is shown through the existence of the domain structure of its own. Often containing a hydrophobic patch, the structure of the CUEDC can also exist entirely as a dimer, being domain swapped in nature. When existing in this matter, it acts as a further binding partner for ubiquitin in a higher affinity.