prospec

CSTA Human, GST

  • Name
  • Description
  • Pricings
  • Quantity
  • CSTA Human, GST
  • Cystatin A Human Recombinant, GST tag
  • Shipped with Ice Packs

Catalogue number

PRO-543

Synonyms

Cystatin-A, Cystatin-AS, Stefin-A, CSTA, STF1, STFA.

Introduction

Cystatin-A is the intracellular inhibitor of cysteine proteinase cathepsin B (CatB) and belongs to family 1 of the cystatin superfamily of inhibitor proteins. CSTA is a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. It has been proposed that extracellular CatB together with other classes of proteinases are all subjected to a cascade-like manner of activation. CatB and its inhibitor Cystatin-A are involved in degradation of extracellular matrix proteins during tissue remodeling. CSTA is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Cystatin-A has been reported to be found in high concentrations in epithelial cells, polymorphonuclear leukocytes and lymphoid tissue. Stefins may be used as prognostic and diagnostic tools for cancer.

Description

Cystatin-A Human Recombinant full length protein expressed in E.coli, shows a 37 kDa band on SDS-PAGE (including GST tag).
The Cystatin-A is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile Filtered clear solution.

Formulation

Cystatin-A in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.

Stability

Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
Please prevent freeze-thaw cycles.

Safety Data Sheet

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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