About CHMP / Chromatin Modifying Protein:
There are many different types of proteins, and Chromatin Modifying Proteins represent a varied and big range of proteins that carry out a number of different epigenetic functions.
They are able to influence gene expression because they have the ability to modify histones, adjust chromatin conformation, and bind DNA. This means that Chromatin Modifying Proteins are powerful targets for research into epigenome and possible therapeutic targets.
Chromatin Modifying Protein Mechanism
There are a number of different types of Chromatin Modifying Proteins. One example is PcG, which stands for polycomb group proteins. These proteins have the responsibility of differentiating cells throughout their development by the use of transcriptional repression.
There has been an intense amount of study regarding this type of Chromatin Modifying Protein. This is because it is evident that they play a critical role in identifying cell-type, differentiation, and disease by the creation and maintenance of environments that are repressive chromatin by forming one of the two major PRC (polycomb repressive complexes), which are PRC2 and PRC1.
Another type of Chromatin Modifying Protein that we will mention is the HDAC class, which stands for histone deacetylases. These proteins have the responsibility of removing the acetyl groups put on histones by HATs, otherwise known as histone acetyltransferases. This process is a critical element of epigenetic gene expression regulation. In more general terms, it is also imperative in terms of cellular stability control.
Other types of Chromatin Modifying Protein s include zinc finger proteins, heterochromatin protein 1, histone acetyltransferases, and much more.