prospec
CFH Rat

CFH Rat

  • Name
  • Description
  • Cat#
  • Pricings
  • Quantity
  • CFH Rat

  • Complement Factor H Rat
  • PRO-2709
  • Shipped with Ice Packs

Catalogue number

PRO-2709

Synonyms

Complement factor H, H factor 1, CFH, HF, HF1, HF2.

Introduction

Complement factor H (CFH) is an important regulatory component of the alternative pathway of complement. CFH is prevents complement activation on host cells and tissues, mainly the kidney. CFH controls the formation and decay of the alternative pathway C3/C5 convertase and acts as a cofactor for factor I which proteolytically inactivates C3b when C3b is bound to factor HThe N-terminal 5 domains of CFH bind to C3b and inhibit binding of factor B thus reducing the formation of C3/C5 convertase. CFH also binds to preformed C3/C5 convertases and causes quick release of the catalytic subunit BbThese activities are necessary for controlling the spontaneous activation of the alternative pathway amplification process in plasma. In addition, CFH controls the formation and decay of these enzymes when C3b is attached to the surface of particles.

Description

Rat Complement Factor H produced in Rat plasma having a total molecular mass of 155kDa.

Source

Rat Plasma.

Physical Appearance

Sterile filtered solution.

Formulation

CFH protein solution contains 10mM Sodium phosphate and 145mM NaCl, pH 7.3.

Stability

CFH Rat is stable at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen below -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by SDS-PAGE.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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