About CEBP / CCAAT-Enhancer-Binding Proteins:
These proteins are a six-member transcription factor-family that comprises CEBPs from CEBPα (CEBP alpha) to CEBPζ (CEBPS zeta).
These proteins are heavily involved in gene binding and dimerization for the different regulatory body system functions.
CEBP uses various mechanisms to regulate its interaction with different factors and proteins: activation, acetylation, phosphorylation, and auto regulation. It uses these complex mechanisms to regulate its expression in different physiological levels regulated by hormones, cytokines, nutrients, and others.
CCAAT-Enhancer-Binding Proteins Structure
All CEBP members bar the CEBPϒ have a functional activation domain that initiates transcription for essential interaction. Four of the family's six elements do not have introns, while the CEBP gamma contains four exons.
These diverse gen combinations within the family have different DNA and RNA binding interactions.
Different types of CEBPs produce different types of polypeptides. It is vital to note the types that make non-functional heterodimers like the LIP from the beta variation.
The presence of CCAAT binds with the CEBP and is present in some gen promoters. The bZip domain, which is highly conserved at the C terminus of CEBP and plays a primary role in DNA binding and dimerization, characterizes the interaction of the CBEP.
CCAAT-Enhancer-Binding Proteins Function
CEBP is an enhanced binding protein that has various uses in the medical field. The primary function of CEBP is to regulate the body's metabolism and inflammation and other types of responses, and build immunity in the body system.
Every kind of CEBPs performs a particular role in proteolysis during the interaction and activation.
CEBP's importance to the nervous system is unmatched as it helps develop the nerve cells and ensure proper functionality. It takes adequate interaction through the different mechanisms to achieve this functionality.