prospec
C3 Human

C3 Human

  • Name
  • Description
  • Cat#
  • Pricings
  • Quantity
  • C3 Human

  • Complement C3 Human
  • PRO-2684
  • Shipped with Ice Packs

Catalogue number

PRO-2684

Synonyms

Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, C3, CPAMD1.

Introduction

Native human C3 is a naturally glycosylated polypeptide containing two disulfide-linked chains. C3 is central to the activation of all 3 pathways of complement activation. Initiation of each pathway generates proteolytic enzyme complexes which binds the target surface. These enzymes cleave a peptide bond in C3 releasing the anaphylatoxin C3a and activating C3b.  Most of the C3 activated during complement activation never attaches to the surface due to its thioester reaction with water forming fluid phase C3b which is rapidly inactivated by factors H and I forming iC3b. Surface-bound C3b is necessary in all 3 pathways for efficient activation of C5 and formation of C5b-9 complexes that lyse the target cell membrane.

Description

Human Complement C3 produced in Human plasma having a molecular mass of 185 kDa.

Source

Human Plasma.

Physical Appearance

Sterile Filtered solution.

Formulation

10mM sodium phosphate and 145mM NaCl, pH 7.2.

Stability

C3 Human is stable at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen below -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by SDS-PAGE.

Human Virus Test

Plasma from each donor has been tested and found negative for antibody to HIV-1,
HIV-2, HCV, HTLV-I &II, STS and HBSAG.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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