prospec
C1S Human

C1S Human

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  • C1S Human

  • Complement C1s Human
  • ENZ-1164
  • Shipped with Ice Packs

Catalogue number

ENZ-1164

Synonyms

Complement C1s subcomponent, C1 esterase, Complement component 1 subcomponent s, C1S.

Introduction

C1s enzyme (a subunit of the C1 complex) is the activated form of C1s proenzyme which is the first complement component in the classical pathway of complement. C1s proenzyme is an inactive zymogen until C1 is activated. C1 is a non-covalent calcium-dependent complex containing1 C1q, 2 C1r and 2 C1s molecules.The binding of multiple arms to immune complexes causesthe production of 2 proteases that cleave and activate the 2 C1s protease zymogens in the complex by the C1r proteins. This activation of C1s proenzyme results in its cleavage into 2 C1s chains of 58,000 and 28,000 Dalton.

Description

Human Complement C1s produced in Human plasma having a molecular mass of 86 kDa.

Source

Human Plasma.

Physical Appearance

Sterile Filtered solution.

Formulation

10mM sodium phosphate and 145mM NaCl, pH 7.2.

Stability

Human C1s is stable at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen below -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Greater than 90.0% as determined by SDS-PAGE.

Human Virus Test

Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HTLV-I &II, STS and HBSAG.

Safety Data Sheet

Usage

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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