C1R Human

C1R Human

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  • C1R Human

  • Complement C1r Human
  • ENZ-1163
  • Shipped with Ice Packs

Catalogue number



Complement C1r subcomponent, Complement component 1 subcomponent r, C1R.


C1r enzyme is the activated form of C1r proenzyme which is inactive zymogen until C1 is activated.C1r is a subunit of the C1 complex which is the first complement component in the classical pathway of complement. C1 is a non-covalent calcium-dependent complex containing1 C1q, 2 C1r and 2 C1s molecules.Each C1q bindsthe Fc domains of IgG or IgM by using2 or more of its six arms. The binding of multiple arms to immune complexes causesthe production of 2 proteases that cleave and activate the 2 C1s protease zymogens in the complex by the C1r proteins. The activation of C1r results from cleavage of C1r into 2 fragments of 57,000 and 35,000 Dalton.


Human Complement C1r produced in Human plasma having a molecular mass of 92 kDa.


Human Plasma.

Physical Appearance

Sterile Filtered solution.


(1mg/ml) 140mM NaCl, 10mM Imidazole and 8mM EDTA, pH 7.4.


Human C1r is stable at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen below -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles


Greater than 90.0% as determined by SDS-PAGE.

Human Virus Test

Plasma from each donor has been tested and found negative for antibody to  HIV-1, HIV-2, HCV, HTLV-I/II, STS and HBSAG.

Safety Data Sheet


ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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