Brain-Derived Neurotrophic Factor, BDNF, MGC34632, Abrineurin, ANON2, BULN2.
BDNF promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. BDNF is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the cns. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (ltp), long-term depression (ltd), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
BDNF Human Recombinant is a single, glycosylated polypeptide chain containing 116 amino acids (19-128a.a) and having a molecular mass of 13.1kDa (calculated). BDNF is fused to a 6 a.a His tag at C-terminal.
BDNF filtered (0.4 µm) and lyophilized from 0.5mg/ml in PBS.
It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely.
Greater than 95.0% as determined by SDS-PAGE.
Amino acid sequence
APMKEANIRG QGGLAYPGVR THGTLESVNG PKAGSRGLTS LADTFEHVIE ELLDEDQKVR PNEENNKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR HHHHHH.
Safety Data Sheet
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