BATF

BATF

BATF

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  • View Data Sheet

    Description:

    Basic Leucine Zipper Transcription Factor ATF-Like 3 Human Recombinant

    JDP1, JUNDM1, SNFT, Basic leucine zipper transcriptional factor ATF-like 3, B-ATF-3, 21 kDa small nuclear factor isolated from T-cells, Jun dimerization protein p21SNFT, BATF3.

    Product # :

    PRO-1871

    Price :

    Quantity :

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    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    BATF3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 150 amino acids (1-127 a.a) and having a molecular mass of 16.9kDa. BATF3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    BATF3 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 30% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Basic Leucine Zipper Transcription Factor ATF-Like 3 (BATF3) which is localizes to the nucleus, contains 1 bZIP domain. BATF3 functions as a negative regulator of AP-1-mediated transcription when interacting with c-Jun, particularly by heterodimerizing with c-Jun and binding to DNA response elements. BATF3 also takes part in repression of interleukin-2.

    • Synonyms

      JDP1, JUNDM1, SNFT, Basic leucine zipper transcriptional factor ATF-like 3, B-ATF-3, 21 kDa small nuclear factor isolated from T-cells, Jun dimerization protein p21SNFT, BATF3.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSQGLPA AGSVLQRSVA APGNQPQPQP QQQSPEDDDR KVRRREKNRV AAQRSRKKQT QKADKLHEEY ESLEQENTML RREIGKLTEE LKHLTEALKE HEKMCPLLLC PMNFVPVPPR PDPVAGCLPR.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Batf3 Human
  • View Data Sheet

    Description:

    Basic Leucine Zipper Transcription Factor Human Recombinant

    Basic leucine zipper transcriptional factor ATF-like, B-cell-activating transcription factor, B-ATF, SF-HT-activated gene 2 protein, SFA-2, BATF, SFA2, BATF1.

    Product # :

    PRO-119

    Price :

    Quantity :

    Shipping Method :

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    Shipped with Ice Packs

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    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    BATF Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 145 amino acids (1-125 a.a.) and having a molecular mass of 16.2kDa. The BATF is purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The BATF solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl and 40% glycerol.

    Purity

    BATF purity was found to be greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      BATF is a nuclear basic leucine zipper protein which is a member of the AP-1/ATF superfamily of transcription factors. BATF is intensely expressed in mature T and B lymphocytes, and is up-regulated after transformation by human T-cell leukemia virus type I. BATF acts as a tissue-specific modulator of the AP-1 transcription complex in human cells. Furthermore, BATF connects with IFP35 which is a leucine zipper protein that translocates to the nucleus following IFN treatment.

    • Synonyms

      Basic leucine zipper transcriptional factor ATF-like, B-cell-activating transcription factor, B-ATF, SF-HT-activated gene 2 protein, SFA-2, BATF, SFA2, BATF1.

    • Physical Appearance

      BATF is supplied as a sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MPHSSDSSDS SFSRSPPPGK QDSSDDVRRV QRREKNRIAA QKSRQRQTQK ADTLHLESED LEKQNAALRK EIKQLTEELK YFTSVLNSHE PLCSVLAAST PSPPEVVYSA HAFHQPHVSS PRFQP.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Batf Human

About BATF / Basic Leucine Zipper Transcription Factor Protein:

BATF is a gene that encodes the bzip transcriptional factor in humans.
The BATF gene has been associated with lymphoma types, hence the heavy research on its function, structure, and mechanism.

BATF Mechanism
BATF is an inhibiting factor of the AF protein group. The bzip is in the Aft/ AP1 transcription factors. These factors significantly influence the immune system that you inherit from your family tree using the different types of T helper cells. Its ability to bind with the DNA either by sequence-specific or transcription factor DNA binding has birthed its solution.
To combat the effects of the BATF2, the JUNB heterodimer combines with the BATF to form complex immune cells. The immune cells then combine to create a regulatory element in the immune system. It controls the differential of the various T cells to maintain their amount in the system.

Basic Leucine Zipper Transcription Factor Function
BATF is used in the evaluation and analysis of the development of the lymphocyte. It utilizes the amount of CD4 cell count in your body by analyzing the results against the average human being's required amount. During the BATF test in mice, T cells' level drastically reduces to almost zero once they are injected with the gene. The B cells in the mice remain intact after the immunization. It has caused doubt and inconclusive tests in the report. Further mice tests are ongoing to determine BATF’s side effects on the B and T cells.