Transmembrane Emp24-Like Trafficking Protein 10 (Yeast), Transmembrane Emp24 Domain-Containing Protein 10, 21 KDa Transmembrane Trafficking Protein, P24 Family Protein Delta-1, p24delta1, Transmembrane Protein Tmp21, S31III125, TMP21, Tmp-21-I, p23.
TMED10, which has a GOLD domain, belongs to the EMP24/GP25L/p24 family. TMED10, a type I membrane protein is restricted to the plasma membrane and golgi cisternae and takes part in vesicular protein transferring. Additionally, TMED10 is a fragment of the heteromeric secretase complex and controls the complex's gamma- secretase activity without influencing its epsilon-secretase activity. Alterations in TMED10 are linked to early-onset familial Alzheimer's disease. TMED10 has a pseudogene on chromosome 8.
TMED10 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 177 amino acids (32-185) and having a molecular mass of 20.0kDa.
TMED10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Sterile filtered colorless solution.
The TMED10 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 30% glycerol.
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Greater than 85% as determined by SDS-PAGE.
Amino acid sequence
MGSSHHHHHH SSGLVPRGSH MGSISFHLPI NSRKCLREEI HKDLLVTGAY EISDQSGGAG GLRSHLKITD SAGHILYSKE DATKGKFAFT TEDYDMFEVC FESKGTGRIP DQLVILDMKH GVEAKNYEEI AKVEKLKPLE VELRRLEDLS ESIVNDFAYM KKREEEMRDT NESTNTR
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