prospec

PDX-1 antibody

  • Name
  • Description
  • Pricings
  • Quantity
  • PDX-1 antibody
  • Pancreas Duodenum Homeobox-1, Polyclonal Rabbit Antibody
  • Shipped at Room temp.

Catalogue number

ANT-162

Synonyms

IPF1, IUF1, IDX-1, MODY4, PDX1, STF-1, Insulin promoter factor 1, Pancreas Duodenum Homeobox-1.

Type

Polyclonal Rabbit Antibody.

Introduction

PDX1 activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. IPF1 is particularly involved in glucose-dependent regulation of insulin gene transcription. Pancreas Duodenum Homeobox-1 binds preferentially the DNA motif 5'-[ct]taat[tg]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, it is required for maintaining the hormone-producing phenotype of the beta-cell.

Immunogen

Recombinant PDX1 E.Coli derived.

Specificity

Human and Mouse PDX-1.

Molecular Weight

35-40 kDa.

Stability

Stable for 2 yeas at -20°C. Avoid freeze/thaw cycles.

Applications

Western Blot: 1:1,000
Immunohistochemistry: 1:500
Optimal working dilutions must be determined by end user.
Routinely evaluated by western blot on lysates of rat pancreatic cell line INS-1

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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