prospec

LAIR1 Human

  • Name
  • Description
  • Pricings
  • Quantity
  • LAIR1 Human
  • Leukocyte-Associated Ig-Like Receptor 1 Human Recombinant
  • Shipped with Ice Packs

Catalogue number

PRO-431

Synonyms

Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305.

Introduction

LAIR1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region.
LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Description

LAIR1 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 105 and having a molecular mass of 11.5 kDa. The extracellular domain of LAIR-1 (22-125aa) was overexpressed in E.coli, and purified by using conventional chromatography techniques.

Source

Escherichia Coli.

Physical Appearance

Sterile filtered colorless solution.

Formulation

The protein (1mg/ml) contains 20mM Tris-HCl (pH7.5) 50mM NaCl and 1mM EDTA.

Stability

Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.

Purity

Greater than 95.0% as determined by SDS-PAGE.

Amino acid sequence

MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG.

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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